Associations with publication and assessing publication bias in dementia diagnostic test accuracy studies

International Journal of Geriatric Psychiatry
Claire WilsonTerence J Quinn

Abstract

Biomarkers are of increasing interest in dementia research. Studies describing favourable accuracy of various dementia tests have influenced research, guidelines and diagnostic criteria. Publication bias is known to compromise reports on efficacy of therapeutic interventions. Traditional methods of quantifying publication bias are not suited to reviews of diagnostic tests. We aimed to describe rates and predictors of publication of dementia test accuracy studies presented at scientific meetings. We chose three exemplar scientific meetings from 2009. Two independent researchers assessed conference proceedings and selected all abstracts relating to dementia diagnostics. We recorded basic descriptors and dichotomised results as 'positive' or 'neutral'. We assessed publication status using electronic literature databases and contacting lead authors. We described univariate and multivariate predictors of publication status using logistic regression modelling. From n = 2257 abstracts, we identified n = 250 (11%) abstracts relating to dementia diagnostics. The majority n = 209 (84%) reported positive results. Only 97 (39%) of these studies are published. Univariate predictors of publication status included positive result (p = 0.042),...Continue Reading

References

Apr 13, 1991·Lancet·P J EasterbrookD R Matthews
Feb 6, 1998·BMJ : British Medical Journal·M Egger, G D Smith
Jul 24, 1998·JAMA : the Journal of the American Medical Association·M L CallahamG Young
Jun 1, 2002·JAMA : the Journal of the American Medical Association·Carin M OlsonBrian Pace
May 31, 2003·BMJ : British Medical Journal·Joel LexchinOtavio Clark
Jun 24, 2004·Journal of the American Geriatrics Society·Joshua ChodoshNeil Wenger
Oct 31, 2006·PLoS Clinical Trials·Elizabeth Wager
Oct 12, 2010·Lancet Neurology·Bruno DuboisPhilip Scheltens
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Nov 1, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Anna H Noel-StorrRupert McShane
Sep 21, 2013·Age and Ageing·David J StottPeter Langhorne
Jun 3, 2014·BMC Medical Research Methodology·W Annefloor van EnstMariska M Leeflang
Dec 11, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M BraininUNKNOWN Post Stroke Cognition Study Group

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Citations

Jun 18, 2016·Journal of Clinical Epidemiology·Daniël A KorevaarPatrick M M Bossuyt
Nov 28, 2018·The Cochrane Database of Systematic Reviews·Roberta W SchererErik von Elm
May 24, 2019·Neurosurgery·Terence J Quinn, David McMahon
Jun 21, 2017·Clinical Chemistry·Daniël A KorevaarPatrick M M Bossuyt
Jan 26, 2020·Research Synthesis Methods·Daniël A KorevaarPatrick M Bossuyt
Jun 9, 2016·BMC Medical Research Methodology·Daniël A KorevaarPatrick M M Bossuyt
Mar 23, 2018·European Radiology·A Dehmoobad SharifabadiM D F McInnes
Jul 21, 2021·The Cochrane Database of Systematic Reviews·Jenny McCleeryTerry J Quinn

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