Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies

Science
J B ConnollyC J O'Kane

Abstract

Disruptions in mushroom body (MB) or central complex (CC) brain structures impair Drosophila associative olfactory learning. Perturbations in adenosine 3',5' monophosphate signaling also disrupt learning. To integrate these observations, expression of a constitutively activated stimulatory heterotrimeric guanosine triphosphate-binding protein alpha subunit (Galphas*) was targeted to these brain structures. The ability to associate odors with electroshock was abolished when Galphas* was targeted to MB, but not CC, structures, whereas sensorimotor responses to these stimuli remained normal. Expression of Galphas* did not affect gross MB morphology, and wild-type Galphas expression did not affect learning. Thus, olfactory learning depends on regulated Gs signaling in Drosophila MBs.

References

Sep 18, 1992·Cell·W J Tang, A G Gilman
May 10, 1991·Science·M I SimonN Gautam
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·F QuanM A Forte
Sep 1, 1985·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·T Tully, W G Quinn
Feb 1, 1985·Journal of Neurogenetics·M HeisenbergD Byers
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·E YehG L Boulianne
May 12, 1995·Science·E Kandel, T Abel
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z L WuD R Storm
Oct 7, 1994·Cell·T TullyM Del Vecchio
Jan 1, 1994·Annual Review of Neuroscience·D E Clapham
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J S de Belle, M Heisenberg

❮ Previous
Next ❯

Citations

Jul 20, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Roman, R L Davis
Feb 7, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Heisenberg
Jan 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M P Belvin, J C Yin
Dec 18, 2002·Journal of Neurobiology·Josh DubnauTim Tully
Jul 9, 2008·Biological cybernetics·Darren SmithBarbara Webb
Feb 26, 2009·Biological cybernetics·Francisco B Rodríguez, Ramón Huerta
Feb 2, 2013·Behavior Genetics·Alfredo GhezziNigel S Atkinson
Sep 6, 2002·Journal of Molecular Neuroscience : MN·Roderick ScottTim Tully
Nov 24, 2001·Trends in Genetics : TIG·S Waddell, W G Quinn
May 24, 2000·Progress in Neurobiology·M Tissot, R F Stocker
Oct 15, 2003·Behavioural Processes·Kathleen K. Siwicki, Lisa Ladewski
Mar 10, 2001·Current Opinion in Neurobiology·T Zars
Jun 23, 1998·Current Biology : CB·J B Connolly, T Tully
Apr 25, 2003·Gene Expression Patterns : GEP·Young-Cho KimKyung-An Han
Jun 21, 2013·Nature·Omer Ali Bayraktar, Chris Q Doe
Oct 23, 1997·Nature Biotechnology·T Misteli, D L Spector
May 3, 2011·Nature Methods·Hanchuan PengJulie H Simpson
Jun 16, 2009·Nature Neuroscience·Hung-Hsiang YuTzumin Lee
Oct 16, 2012·Nature Neuroscience·Taro UenoKazuhiko Kume
Apr 2, 2009·Nature Reviews. Drug Discovery·Sandra PierreKlaus Scholich
Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jason ClementsPatrick Callaerts
Oct 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pavel Masek, Martin Heisenberg
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·David L Glanzman
Aug 19, 2010·Human Molecular Genetics·David J MelicharekDaniel R Marenda
Jan 2, 2009·Learning & Memory·Lisa C Lyons, Gregg Roman
Sep 19, 2006·Learning & Memory·David-Benjamin G AkalalRonald L Davis
Oct 4, 2006·Learning & Memory·Björn Brembs, Jan Wiener
Dec 5, 2006·Learning & Memory·Rusiko BourtchouladzeTed Abel
Jun 1, 2004·Learning & Memory·Andreas MershinEfthimios M C Skoulakis
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·K FoltenyiR J Greenspan
Mar 31, 2007·Development, Growth & Differentiation·Kazuma Fushima, Hidenobu Tsujimura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.