PMID: 11926416Apr 3, 2002Paper

Assumptions of the tumor 'escape' hypothesis

Seminars in Cancer Biology
Nicholas P RestifoChristopher E Touloukian

Abstract

The reasons why cancer cells are not destroyed by the immune system are likely to be similar, in most cases, to the reasons why normal cells are not destroyed by the immune system. Unfortunately for tumor immunologists, these reasons have not yet been fully elucidated. What is known, however, is that the lack of autoimmune destruction of normal tissue after immune activation is a finely regulated, highly orchestrated sequence of events. Viewed in this light, it is interesting to conceptualize the derangement of the tumor genome not merely as an engine that enables cancer cells to dodge immune recognition. The dysregulation characteristic of the transformed genome is also what makes tumor immunity, a specialized form of autoimmunity, possible.

Citations

Oct 31, 2002·Nature Immunology·Hung T Khong, Nicholas P Restifo
Dec 14, 2011·Clinical & Developmental Immunology·Steven Eric FinkelsteinGeorge D Wilson
Oct 10, 2006·Cancer Metastasis Reviews·Michael R ShurinRobert L Ferris
Sep 29, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Steven De VleeschouwerFrank Van Calenbergh
Apr 21, 2010·Cancer Control : Journal of the Moffitt Cancer Center·Sarah E HoffeRavi Shridhar
Aug 20, 2011·Drug and Chemical Toxicology·Lars SteinstraesserFrank Jacobsen
Apr 21, 2010·Cancer Control : Journal of the Moffitt Cancer Center·Jennifer L GigliaSteven E Finkelstein
Nov 5, 2020·Journal of Clinical Medicine·Mihnea P DragomirGeorge A Calin
Mar 15, 2011·International Journal of Radiation Oncology, Biology, Physics·Steven E FinkelsteinDmitry I Gabrilovich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.