AST/ALT ratio is not useful in predicting the degree of fibrosis in chronic viral hepatitis patients

European Journal of Gastroenterology & Hepatology
Ahmet Tarik EminlerSelim G Nak

Abstract

Noninvasive tests are primarily used for staging hepatic fibrosis in patients with chronic liver disease. In clinical practice, serum aminotransferase levels, coagulation parameters, and platelet count have been used to predict whether or not a patient has cirrhosis. In addition, several studies have evaluated the accuracy of combinations (or ratios) of these measures. The present study aimed to investigate the relationship between five noninvasive models [AST/ALT ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), Bonacini cirrhosis discriminant score (CDS), age-platelet index (APind), and King's score] and the degree of hepatic fibrosis as determined by biopsy in patients with chronic hepatitis B and C. A total of 380 patients with viral hepatitis (237 with chronic hepatitis B and 143 with chronic hepatitis C) who were seen at our clinic between January 2005 and January 2011 were retrospectively analyzed. The degree of fibrosis was determined using the Ishak score. Patients with a fibrosis score of 0-2 were considered to have low fibrosis and those with a score between 3 and 6 were considered to have high fibrosis. Five noninvasive models were compared between the groups with low and high fibrosis. There w...Continue Reading

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Citations

Jan 1, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jianxue LiuSujuan Guo
Jan 10, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Minhui DongJiming Zhang
May 23, 2019·Journal of Clinical Laboratory Analysis·Lingyan LiuJie Xu
Sep 9, 2017·European Journal of Gastroenterology & Hepatology·Sonja LangMünevver Demir
Apr 30, 2019·European Journal of Gastroenterology & Hepatology·Aziz A HamidiIlyas Dokmetas
May 12, 2019·Journal of Viral Hepatitis·Dalia Morales-ArraezManuel Hernández-Guerra
Nov 21, 2020·BMC Immunology·Leonn Mendes Soares PereiraAntonio Carlos Rosário Vallinoto
Jan 5, 2021·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Pilar Del Pino BellidoIsabel Carmona Soria
May 21, 2020·European Journal of Gastroenterology & Hepatology·Adam PrzybyłkowskiAnna Członkowska

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS

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