Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity

Scientific Reports
Ji Hye HanJin Tae Hong

Abstract

Astaxanthin (AXT) is classified as a xanthophyll carotenoid compound which have broader functions including potent antioxidant, anti-inflammatory and neuroprotective properties. Considerable researches have demonstrated that AXT shows preventive and therapeutic properties against for Diabetes, Osteoarthritis and Rheumatoid Arthritis. However, the protective effect of AXT on liver disease has not yet been reported. In this study, we investigated effects of AXT on ethanol-induced liver injury in chronic plus binge alcohol feeding model. The hepatic steatosis and inflammation induced by ethanol administration were alleviated by AXT. Serum levels of aspartate transaminase and alanine transaminase were decreased in the livers of AXT administrated group. The ethanol-induced expression of cytochrome P450 2E1 (CYP2E1), pro-inflammatory proteins, cytokines, chemokines and reactive oxygen species (ROS) levels were also reduced in the livers of AXT administrated group. Moreover, ethanol-induced infiltration of neutrophils was decreased in the livers of AXT administrated group. Docking model and pull-down assay showed that AXT directly binds to the DNA binding site of STAT3. Moreover, AXT decreased STAT3 phosphorylation in the liver of AXT...Continue Reading

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Citations

Jul 2, 2020·Drug Design, Development and Therapy·Jingjing LiJianye Wu
Jan 7, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Robin D Clugston
Feb 13, 2021·Antioxidants·Maria-Luisa Pérez-LozanoHechmi Toumi
Nov 28, 2019·Analytical Chemistry·Matthew LindleyKeisuke Goda
Sep 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhengze LuQin He
Dec 18, 2021·Journal of Medicinal Chemistry·Zohreh JafariPooyan Makvandi

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Methods Mentioned

BETA
PCR
transfection
Assay

Software Mentioned

AutoDock
GraphPad Prism
Discovery Studio Visualizer
- Pad
Graph
AutoDock VINA

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