Jul 9, 2020

Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging

Marine Drugs
Vincenzo SorrentiDonald C Willcox

Abstract

In recent years, the scientific interest in natural compounds with geroprotective activities has grown exponentially. Among the various naturally derived molecules, astaxanthin (ASX) represents a highly promising candidate geroprotector. By virtue of the central polyene chain, ASX acts as a scavenger of free radicals in the internal membrane layer and simultaneously controls oxidation on the membrane surface. Moreover, several studies have highlighted ASX's ability to modulate numerous biological mechanisms at the cellular level, including the modulation of transcription factors and genes directly linked to longevity-related pathways. One of the main relevant evolutionarily-conserved transcription factors modulated by astaxanthin is the forkhead box O3 gene (FOXO3), which has been recognized as a critical controller of cell fate and function. Moreover, FOXO3 is one of only two genes shown to robustly affect human longevity. Due to its tropism in the brain, ASX has recently been studied as a putative neuroprotective molecule capable of delaying or preventing brain aging in different experimental models of brain damage or neurodegenerative diseases. Astaxanthin has been observed to slow down brain aging by increasing brain-derive...Continue Reading

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Mentioned in this Paper

Membranous Layer
Study
Brain Injuries
BDNF gene
Forkhead Box Protein O3
NF-E2-Related Factor 2
Genes
KL
Modulated
FOXO3 gene

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