Astaxanthin Combine with Human Serum Albumin to Abrogate Cell Proliferation, Migration, and Drug-resistant in Human Ovarian Carcinoma SKOV3 Cells

Anti-cancer Agents in Medicinal Chemistry
Xiu-Zhen SuMing-Yi Zhu

Abstract

Astaxanthin (AST) shows a large range of beneficial effects together with anti-cancer and antioxidation properties. Human Serum Albumin (HSA) is the most abundant protein in blood plasma which plays the role of a depot and transport protein for many exogenous compounds. However, whether HSA could enhance AST-induced cytotoxic effects in human ovarian cancer cells has not been examined to date. This study aims to explore the anticancer effect and the molecular mechanism of AST combine with HSA induced cytotoxicity in ovarian cancer SKOV3 cells. The ovarian cancer SKOV3 cells were treated by AST combined with HSA to study the effects of cell proliferation, cell morphology, cell cycle arrest, related protein expression, nuclear transfer, cell migration, and drug-resistant. Our data confirmed that AST+HSA treatment enhanced the anticancer effects of AST, arrested G1 phase cell cycle and induced apoptosis in SKOV3 cells. AST+HSA induced apoptosis via mitochondrial apoptotic pathways was related to the increased ratio of Bcl-2/Bax and activation of caspase-3. Besides, exposure of cells to AST+HSA triggered the inactivation of NF-κB and activation p53 and MAPKs signaling pathways. Furthermore, AST+HSA significantly overcome the drug-r...Continue Reading

References

Jul 16, 1992·Nature·X M He, D C Carter
Sep 16, 2003·Journal of Cell Science·Susan HauptYgal Haupt
Aug 27, 2004·Nature·Eli PikarskyYinon Ben-Neriah
Oct 4, 2005·The Journal of Clinical Investigation·Jun-Li LuoMichael Karin
Sep 24, 2011·Nature Reviews. Cancer·Sebastian VaughanFrances R Balkwill
Jan 20, 2012·Nature Reviews. Cancer·Neil D Perkins
Feb 6, 2013·Nature Reviews. Clinical Oncology·Robert L ColemanThomas J Herzog
Mar 12, 2013·Journal of Agricultural and Food Chemistry·Ambati Ranga RaoGokare Aswathanarayana Ravishankar
Apr 27, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaoguang LiHui Wang
Jun 7, 2014·Journal of the American Chemical Society·Yao-Rong ZhengStephen J Lippard
Feb 28, 2015·Food Chemistry·Xiangrong LiYan Lu
Oct 12, 2016·Journal of Agricultural and Food Chemistry·Xiaojuan LiuHang Xiao
May 18, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Poorigali Raghavendra-Rao SowmyaRangaswamy Lakshminarayana

❮ Previous
Next ❯

Citations

Sep 2, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seyede Nazanin ZarneshanLuciano Saso
Dec 17, 2020·Biomolecules·Lenka KoklesovaPeter Kubatka
Feb 4, 2021·International Journal of Molecular Sciences·Marta WoźniakSiddarth Agrawal
Feb 15, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Immacolata FaraoneHaroon Khan
Apr 13, 2021·Journal of Food Biochemistry·Zhen LinHuazhong Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.