Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism

Behavioural Brain Research
Md Mamun Al-AminHasan Mahmud Reza

Abstract

Prenatal exposure to valproic acid on gestational day 12.5 may lead to the impaired behavior in the offspring, which is similar to the human autistic symptoms. To the contrary, astaxanthin shows neuroprotective effect by its antioxidant mechanism. We aimed to (i) develop mice model of autism and (ii) investigate the effect of astaxanthin on such model animals. Valproic acid (600 mg/kg) was administered intraperitoneally to the pregnant mice on gestational day 12.5. Prenatal valproic acid-exposed mice were divided into 2 groups on postnatal day 25 and astaxanthin (2mg/kg) was given to the experimental group (VPA_AST, n=10) while saline was given to the control group (VPA, n=10) for 4 weeks. Behavioral test including social interaction, open field and hot-plate were conducted on postnatal day 25 and oxidative stress markers such as lipid peroxidation, advanced protein oxidation product, nitric oxide, glutathione, and activity of superoxide dismutase and catalase were estimated on postnatal day 26 to confirm mice model of autism and on postnatal day 56 to assess the effect of astaxanthin. On postnatal day 25, prenatal valproic acid-exposed mice exhibited (i) delayed eye opening (ii) longer latency to respond painful stimuli, (iii)...Continue Reading

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Citations

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Apr 12, 2019·Frontiers in Neuroscience·Md Mamun Al-AminHasan Mahmud Reza
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Jun 26, 2018·Frontiers in Neuroscience·Md Mamun Al-AminHasan Mahmud Reza
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Jul 10, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica J WalshRobert C Malenka
Aug 19, 2020·Developmental Neuroscience·Devahuti ChalihaJohn Mamo

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