Astaxanthin Prevents Alcoholic Fatty Liver Disease by Modulating Mouse Gut Microbiota

Nutrients
Huilin LiuJingsheng Liu

Abstract

The development and progression of alcoholic fatty liver disease (AFLD) is influenced by the intestinal microbiota. Astaxanthin, a type of oxygenated carotenoid with strong antioxidant and anti-inflammatory properties, has been proven to relieve liver injury. However, the relationship between the gut microbiota regulation effect of astaxanthin and AFLD improvement remains unclear. The effects of astaxanthin on the AFLD phenotype, overall structure, and composition of gut microbiota were assessed in ethanol-fed C57BL/6J mice. The results showed that astaxanthin treatment significantly relieves inflammation and decreases excessive lipid accumulation and serum markers of liver injury. Furthermore, astaxanthin was shown to significantly decrease species from the phyla Bacteroidetes and Proteobacteria and the genera Butyricimonas, Bilophila, and Parabacteroides, as well as increase species from Verrucomicrobia and Akkermansia compared with the Et (ethanol)group. Thirteen phylotypes related to inflammation as well as correlated with metabolic parameters were significantly altered by ethanol, and then notably reversed by astaxanthin. Additionally, astaxanthin altered 18 and 128 KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways i...Continue Reading

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Citations

Oct 9, 2019·Nutrients·Jaume Amengual
Jun 7, 2020·Antioxidants·Elena Rodríguez-RodríguezBegoña Olmedilla-Alonso
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Sep 29, 2021·Critical Reviews in Food Science and Nutrition·Yunrui CaoJie Xu
Jun 1, 2021·Nutrition Research Reviews·Torsten BohnJoanna Dulińska-Litewka

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Datasets Mentioned

BETA
OTU71112

Methods Mentioned

BETA
PCR
electrophoresis
Assay
light microscopy

Software Mentioned

GraPhlAn
QIIME
SPSS
Metastats
GraphPad Prism
UCLUST
PERMANOVA
ANOSIM
BLAST
R

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