Astaxanthin protects steroidogenesis from hydrogen peroxide-induced oxidative stress in mouse Leydig cells

Marine Drugs
Jyun-Yuan WangLeang-Shin Wu

Abstract

Androgens, especially testosterone produced in Leydig cells, play an essential role in development of the male reproductive phenotype and fertility. However, testicular oxidative stress may cause a decline in testosterone production. Many antioxidants have been used as reactive oxygen species (ROS) scavengers to eliminate oxidative stress to protect steroidogenesis. Astaxanthin (AST), a natural extract from algae and plants ubiquitous in the marine environment, has been shown to have antioxidant activity in many previous studies. In this study, we treated primary mouse Leydig cells or MA-10 cells with hydrogen peroxide (H2O2) to cause oxidative stress. Testosterone and progesterone production was suppressed and the expression of the mature (30 kDa) form of StAR protein was down-regulated in MA-10 cells by H2O2 and cAMP co-treatment. However, progesterone production and expression of mature StAR protein were restored in MA-10 cells by a one-hour pretreatment with AST. AST also reduced ROS levels in cells so that they were lower than the levels in untreated controls. These results provide additional evidence of the potential health benefits of AST as a potential food additive to ease oxidative stress.

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Citations

Aug 4, 2016·Journal of Dietary Supplements·Aliasghar VahidiniaMohammad Mehdi Shakoori Mahmoodabadi
Jan 27, 2017·Journal of Zhejiang University. Science. B·Hong-Zhou MengSheng-Rong Shen
Oct 6, 2015·Marine Drugs·Maria Alessandra GammoneNicolantonio D'Orazio
Nov 24, 2017·Antioxidants·Christian GalassoClementina Sansone
Apr 16, 2016·Molecular Medicine Reports·Ting DuanBing Yao
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Nov 25, 2020·Marine Drugs·Toshiki Nakano, Geert Wiegertjes

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Methods Mentioned

BETA
fluorescence microscopy

Software Mentioned

Excel
SigmaStat
VisionWorksLS Image Acquisition and Analysis

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