Astemizole in the treatment of hay fever

Allergy
H MalmbergS Sundberg

Abstract

A double-blind parallel trial of astemizole, pheniramine and placebo was carried out in 51 patients with hay fever. Astemizole is a new potent H1-antihistamine with long duration of action but devoid of central activity. Evaluation criteria were daily symptom- and side effect score cards, daily nasal peak flow measurements, clinical examination and blood tests. Control of nasal symptoms was significantly better with both antihistamines than with placebo. Tiredness and anticholinergic side effects were less common in the astemizole group than in the pheniramine group. No significant changes in the "safety evaluation" blood tests were observed.

References

Jul 1, 1978·Clinical Allergy·C H MalmbergB S Stenius-Aarniala

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Citations

Jun 26, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W H BoehnckeH Gall
Oct 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L BauerD Kraft
Feb 9, 2008·The British Journal of Educational Psychology·Katariina Salmela-AroJari-Erik Nurmi
Dec 1, 1987·Drug Intelligence & Clinical Pharmacy·P M Krstenansky, R J Cluxton

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