PMID: 9632006Jun 19, 1998Paper

Asteroid bodies and other cytoplasmic inclusions in necrobiotic xanthogranuloma with paraproteinemia

Journal of the American Academy of Dermatology
R K WinkelmannP M Dahl

Abstract

Necrobiotic xanthogranuloma (NXG) with paraproteinemia is a distinctive palisading granuloma of the skin. Extracutaneous lesions are rarely present. The purpose of this study was to confirm the presence and significance of giant cell asteroid bodies and other cytoplasmic inclusions in NXG with paraproteinemia. Skin biopsy specimens from 24 patients with NXG with paraproteinemia were reviewed; autopsy and lung biopsy specimens from two patients were stained for iron, calcium, and polysaccharide. Giant cell asteroid bodies were observed in skin biopsy specimens of 8 (33%) of the 24 patients. In addition, large acidophilic polygonal cytoplasmic inclusions were observed in myocardial tissue of one of the autopsy cases. Iron and calcium were not found. Asteroid bodies and other inclusions can be present in the giant cells of NXG with paraproteinemia. They are as frequent as, or more frequent than, in other granulomatous diseases and should be considered in the diagnosis of NXG with paraproteinemia.

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Citations

Oct 26, 2000·The American Journal of Dermatopathology·J StorkM Krejca
Mar 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Fiona F SequeiraUNKNOWN Jayanthi
Nov 14, 2006·Journal of the American Academy of Dermatology·Brenda NewmanAnita C Gilliam
Mar 12, 2008·Journal of Cutaneous Pathology·Franco RongiolettiAlfredo Rebora
Jan 8, 2009·International Journal of Dermatology·Kerith E Spicknall, David A Mehregan
Jul 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·D MiguelP Elsner
Nov 21, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Habibe Kurt, Obiajulu H Iwenofu
Apr 20, 2004·International Journal of Dermatology·Dilek GünCuyan Demirkesen

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