Asthma and height in twins: a cohort and within-pair analyses study

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
Jennifer Lisa Penner ProtudjerCatarina Almqvist

Abstract

In singletons, asthma may be associated with shorter height and delayed growth during adolescence. Yet, these studies do not account for heritability of asthma, puberty/menarche, and height. We aimed to study the association between asthma and puberty in boys and menarche in girls, and height, in a cohort of twins and subsequently in same-sex twin pairs discordant for asthma. From a Swedish twin cohort, parent- and self-reported data on asthma, puberty/menarche, and height were collected. Pubertal staging was established via the Petersen index. Logistic and linear regression was used to estimate associations between asthma and puberty/menarche and height, respectively. For within-pair analyses in twins discordant for asthma, conditional logistic and linear regression were used. Data on 2,658 (49.1% boys) twins were included. Among boys, asthma prevalence was 8.2% at 8-9 years and 10.2% at 13-14 years. Corresponding numbers for girls were 4.2% and 4.9%, respectively. In the entire cohort, no statistically significant associations were found between current asthma and puberty/menarche. Boys with asthma were shorter than boys without asthma at 8-9 years (on average, 1.86 [0.17-3.56] cm, p = .03) and at 13-14 years (on average, 2.9...Continue Reading

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Citations

Jan 28, 2020·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Jeffrey M CraigDedra Buchwald
Sep 19, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Jennifer Lisa Penner ProtudjerAllan Barry Becker
Nov 20, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Maria MovinUNKNOWN Childhood Asthma Prevention Team

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