Asthma and orbital immunoglobulin G4-related disease

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Misbah BaqirJay H Ryu

Abstract

An association has been suggested between asthma and orbital immunoglobulin G4-related disease (IgG4-RD). To explore this association, including asthma characteristics and risk factors. A retrospective, computer-assisted search identified patients with orbital IgG4-RD seen at Mayo Clinic in Rochester, Minnesota from 1997 to 2014. Asthma prevalence and its related clinical and radiologic characteristics were studied. Thirty-one patients (17 men) with biopsy-proven orbital IgG4-RD were identified. Mean age at diagnosis was 54.3 years (SD 11.0 years). Median duration from onset of orbital symptoms to IgG4-RD diagnosis was 1.96 years (range 0.1-31.8 years). Twenty-two patients (71%) were not smokers, 6 (19%) were former smokers, and 3 (10%) were current smokers. Sixteen patients (52%) had asthma. Three patients had childhood asthma onset, and median age at asthma onset in the 7 patients with data available was 56 years (range 15-62 years). In this cohort, the most common findings at chest computed tomography were mediastinal and hilar lymphadenopathy (44%), linear scarring (20%), and nodules and bronchial wall thickening (16%). Bronchial wall thickening correlated with presence of asthma. Chronic sinusitis (94%) was most commonly a...Continue Reading

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Citations

Aug 21, 2018·Ophthalmic Plastic and Reconstructive Surgery·Andrea A TooleyJames A Garrity
Jun 10, 2017·Current Opinion in Ophthalmology·Richard C Allen
Jan 4, 2020·Clinical Rheumatology·Marta Casal MouraMisbah Baqir
Jul 27, 2021·Frontiers in Immunology·Despina MichailidouGrant C Hughes

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