Asthma as a risk factor for COPD in a longitudinal study

Chest
Graciela E SilvaRobert A Barbee

Abstract

For several years, asthma and COPD have been regarded as distinct entities, with distinct clinical courses. However, despite distinctive physiologic features at the time of diagnosis, and different risk factors, the two diseases over time may develop features that are quite similar. To evaluate the association between physician-diagnosed asthma and the subsequent development of COPD in a cohort of 3,099 adult subjects from Tucson, AZ. A prospective observational study. Participants completed up to 12 standard respiratory questionnaires and 11 spirometry lung function measurements over a period of 20 years. Survival curves (with time to development of COPD as the dependent variable) were compared between subjects with asthma and subjects without asthma at the initial survey. Subjects with active asthma (n = 192) had significantly higher hazard ratios than inactive (n = 156) or nonasthmatic subjects (n = 2751) for acquiring COPD. As compared with nonasthmatics, active asthmatics had a 10-times-higher risk for acquiring symptoms of chronic bronchitis (95% confidence interval [CI], 4.94 to 20.25), 17-times-higher risk of receiving a diagnosis of emphysema (95% CI, 8.31 to 34.83), and 12.5-times-higher risk of fulfilling COPD criter...Continue Reading

References

Feb 1, 1976·Annals of Internal Medicine·R A BarbeeB Burrows
Jan 1, 1989·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C H Fanta
Feb 2, 1989·The New England Journal of Medicine·B BurrowsM G Cline
Apr 1, 1988·The American Review of Respiratory Disease·B RijckenR van der Lende
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·B RijckenS T Weiss
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·M TraceyS T Holgate
Sep 1, 1994·American Journal of Respiratory and Critical Care Medicine·C S Ulrik, P Lange
Feb 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C HudonL P Boulet
Oct 22, 1998·The New England Journal of Medicine·P LangeG Jensen
Apr 13, 1999·The Journal of Allergy and Clinical Immunology·C E Reed
Nov 26, 1999·The European Respiratory Journal·C S Ulrik, V Backer
Feb 16, 2000·Chest·P J Barnes
Jun 16, 2000·The Journal of Allergy and Clinical Immunology·A M VignolaJ Bousquet
Feb 26, 2003·Revue des maladies respiratoires·A CuvelierF Chabot

❮ Previous
Next ❯

Citations

Jan 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David L Hahn, Rosanna W Peeling
Feb 19, 2005·Drug Discovery Today·Willem I de Boer
Dec 17, 2005·Current Opinion in Pulmonary Medicine·Judith M Vonk, H Marike Boezen
Jul 30, 2009·Current Opinion in Allergy and Clinical Immunology·Stefano Guerra
Nov 29, 2007·Current Opinion in Pulmonary Medicine·Arthur F GelbAnita Krishnan
Dec 15, 2010·Current Opinion in Pulmonary Medicine·Philippa ShirtcliffeRichard Beasley
May 21, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Matthew L StollNancy A Shadick
Aug 19, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Giovanni ViegiLaura Carrozzi
Aug 4, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yasunari TsudaHideki Takahashi
Apr 23, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kimihiko MuraseKyosuke Ishihara
Aug 2, 2005·Thorax·P M SturdyUNKNOWN National Asthma Campaign Mortality and Severe Morbidity Group
Aug 30, 2008·Thorax·S E MarshR W Beasley
Nov 29, 2011·Journal of Allergy·Amir A ZekiSamuel Louie
Nov 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Charity NofzigerMarkus Paulmichl
Feb 24, 2006·American Journal of Respiratory and Critical Care Medicine·David L Hahn
Oct 25, 2006·American Journal of Respiratory and Critical Care Medicine·David L Hahn
Sep 28, 2010·American Journal of Respiratory and Critical Care Medicine·Zorana J AndersenOle Raaschou-Nielsen
Sep 29, 2011·Respiratory Research·Megan HardinUNKNOWN COPDGene Investigators
Dec 17, 2009·Proceedings of the American Thoracic Society·Stefano Guerra, Fernando D Martinez
May 17, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Yoshiaki KitaguchiKeishi Kubo
Dec 20, 2013·International Journal of Environmental Research and Public Health·Hager DaldoulImed Harrabi
Sep 21, 2013·Lung India : Official Organ of Indian Chest Society·Dheeraj GuptaUNKNOWN S. K. Jindal for the COPD Guidelines Working Group
Aug 6, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Jung Wha ChungJung Hyun Chang
Apr 5, 2007·Cell Biochemistry and Biophysics·Willem I de BoerHari S Sharma
Jun 24, 2014·American Journal of Respiratory and Critical Care Medicine·Daniel W BelskyAvshalom Caspi
Oct 9, 2014·Annals of the American Thoracic Society·Alejandro A DiazUNKNOWN COPDGene Investigators
Mar 6, 2009·Journal of the American Medical Informatics Association : JAMIA·Blanca E HimesMarco F Ramoni
Jul 30, 2011·Metallomics : Integrated Biometal Science·R Steve Pappas
Dec 14, 2004·Current Opinion in Pulmonary Medicine·Stefano Guerra
Jun 6, 2009·Postgraduate Medicine·Zab Mosenifar
Sep 30, 2015·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Claire E HayesSarah Moody-Thomas
May 29, 2007·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Michael SchatzRobert S Zeiger
Nov 21, 2007·COPD·Adam L FriedlanderRussell P Bowler
May 8, 2009·Current Medical Research and Opinion·Christopher M BlanchetteAnand A Dalal
Apr 14, 2012·COPD·Sukanya GangopadhyaySurendra Kumar Bansal
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Kathleen M DonohueR Graham Barr
Jan 21, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroyuki SanoYuji Tohda
Jul 17, 2012·The Medical Clinics of North America·Carlos H Martinez, MeiLan K Han

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.