PMID: 6159383Dec 1, 1980Paper

Asthma caused by occupational exposure to a furan-based binder system

The Journal of Allergy and Clinical Immunology
D W CockcroftF E Hargreave

Abstract

A 50-yr-old mold maker developed severe asthma a few weeks after commencing work with a furan binder. Asthma recurred within hours of subsequent exposure and was confirmed by measurements every 2 hr of peak flow rate. The molds were prepared by mixing sand with a resin (containing furfuryl alcohol, paraformaldehyde, and xylene) and a catalyst (containing sulfuric acid, phosphoric acid, and butyl alcohol). Occupation-type exposure in the laboratory to the resin mixed with catalyst, and to pure furfuryl alcohol mixed with sulfuric acid or butyl alcohol, provoked late asthmatic responses and heightened nonallergic bronchial responsiveness to inhaled histamine. No changes were produced by the same exposures in an asthmatic volunteer with a similar degree of histamine bronchial responsiveness, or in the worker after exposure to resin alone and catalyst alone. Avoidance of exposure was followed by clearing of symptoms and return of histamine bronchial responsiveness towards normal. The findings identify the occurrence of specific bronchial responsiveness to volatile reaction product(s) of furfuryl alcohol following reaction with sulfuric acid or with butyl alcohol. The incidence of this problem needs investigation, especially since f...Continue Reading

References

Aug 1, 1977·The Journal of Allergy and Clinical Immunology·C R ZeissD Levitz
May 1, 1979·The Journal of Allergy and Clinical Immunology·R C AndertonF E Hargreave
Nov 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Jan 1, 1979·The Journal of Allergy and Clinical Immunology·S LamM Yeung
May 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Jan 1, 1972·The Journal of Allergy and Clinical Immunology·M CeskaJ M Varga
Sep 1, 1972·Clinical Allergy·J PepysD J Terry
Nov 1, 1969·Diseases of the Chest·V PopaN Gavrilescu

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Citations

Jan 1, 1991·International Archives of Occupational and Environmental Health·M AhmanU Ulfvarson
Oct 18, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer FrankoStacey E Anderson
Feb 1, 1985·British Journal of Industrial Medicine·I Low, C Mitchell
Sep 28, 2012·Journal of Occupational Medicine and Toxicology·Xaver BaurHenning Vellguth
Jul 14, 2000·American Journal of Industrial Medicine·V van KampenX Baur
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·A CartierJ Y Dubois

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