Asthma Control and Airway Inflammation in Patients with Eosinophilic Granulomatosis with Polyangiitis

The Journal of Allergy and Clinical Immunology. in Practice
Manuela LatorrePierluigi Paggiaro

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic necrotizing vasculitis that occurs in patients with asthma, nasal disease, blood and tissue eosinophilia, and extrapulmonary manifestations. The aim of our study was to assess the clinical, functional, and inflammatory status of upper and lower airways in 37 patients with EGPA, examined 6.4 ± 4.7 years after diagnosis, when they were in partial or complete remission from systemic involvement while on treatment with low-dose oral corticosteroids as maintenance therapy. All patients performed spirometry and were assessed for bronchial hyperreactivity, sputum eosinophilia, and fractional exhaled nitric oxide; asthma control was evaluated according to the Global Initiative for Asthma (GINA) guidelines and the Asthma Control Test. Markers of systemic disease were compared with the data available at diagnosis. Nasal involvement was evaluated by using the Sino-Nasal Outcome Test, nasal endoscopy, and nasal cytology. The impact on the quality of life was evaluated by using generic (36-item short form health survey) and organ-specific questionnaires. At the time of the study visit, almost all patients were receiving low-dose oral corticosteroids and immunomodulating drug...Continue Reading

References

Nov 26, 1999·The European Respiratory Journal·E F JuniperD R King
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·A JatakanonP J Barnes
Oct 17, 2001·Respiratory Medicine·H MezianeP Chanez
Dec 31, 2002·The European Respiratory Journal·M RomagnoliP Chanez
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Aug 16, 2008·American Journal of Rhinology·Ibrahim SroujiChris Edwards

❮ Previous
Next ❯

Citations

Aug 3, 2020·Current Opinion in Pulmonary Medicine·Mouhamad Nasser, Vincent Cottin
Apr 13, 2017·Clinical and Molecular Allergy : CMA·G SennaUNKNOWN SANI
Dec 3, 2020·Therapeutic Advances in Respiratory Disease·Manuela LatorrePierluigi Paggiaro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
V QuaedvliegR Louis
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
N M WilsonA Bush
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Janusz CiółkowskiHenryk Mazurek
© 2022 Meta ULC. All rights reserved