Abstract
Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic necrotizing vasculitis that occurs in patients with asthma, nasal disease, blood and tissue eosinophilia, and extrapulmonary manifestations. The aim of our study was to assess the clinical, functional, and inflammatory status of upper and lower airways in 37 patients with EGPA, examined 6.4 ± 4.7 years after diagnosis, when they were in partial or complete remission from systemic involvement while on treatment with low-dose oral corticosteroids as maintenance therapy. All patients performed spirometry and were assessed for bronchial hyperreactivity, sputum eosinophilia, and fractional exhaled nitric oxide; asthma control was evaluated according to the Global Initiative for Asthma (GINA) guidelines and the Asthma Control Test. Markers of systemic disease were compared with the data available at diagnosis. Nasal involvement was evaluated by using the Sino-Nasal Outcome Test, nasal endoscopy, and nasal cytology. The impact on the quality of life was evaluated by using generic (36-item short form health survey) and organ-specific questionnaires. At the time of the study visit, almost all patients were receiving low-dose oral corticosteroids and immunomodulating drug...Continue Reading
References
Jan 1, 1987·Lung·L GuillevinP Rosenthal
Mar 1, 1984·Medicine·J G LanhamG R Hughes
Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·P L PaggiaroC Giuntini
Feb 1, 1997·Arthritis and Rheumatism·A R ExleyD Adu
Aug 24, 1999·Thorax·A SchnabelW L Gross
Nov 26, 1999·The European Respiratory Journal·E F JuniperD R King
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·A JatakanonP J Barnes
Oct 17, 2001·Respiratory Medicine·H MezianeP Chanez
Dec 14, 2002·Lancet·Ruth H GreenIan D Pavord
Dec 31, 2002·The European Respiratory Journal·M RomagnoliP Chanez
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Jul 11, 2007·Allergy and Asthma Proceedings·Naomi TsurikisawaKazuo Akiyama
Aug 16, 2008·American Journal of Rhinology·Ibrahim SroujiChris Edwards
Jan 22, 2009·Allergy·V CottinJ-F Cordier
Oct 10, 2012·Arthritis and Rheumatism·Cloé ComarmondUNKNOWN French Vasculitis Study Group
Jan 22, 2013·Allergy·A VaglioJ Zwerina
Sep 11, 2014·Rheumatology·Joanna RobsonRaashid Luqmani
Citations
Jul 2, 2019·Rheumatology·Alvise Berti
Nov 26, 2019·Expert Review of Clinical Immunology·Alvise BertiDivi Cornec
Aug 3, 2020·Current Opinion in Pulmonary Medicine·Mouhamad Nasser, Vincent Cottin
Apr 13, 2017·Clinical and Molecular Allergy : CMA·G SennaUNKNOWN SANI
Dec 3, 2020·Therapeutic Advances in Respiratory Disease·Manuela LatorrePierluigi Paggiaro