Asthma-COPD Overlap-A Discordance Between Patient Populations Defined by Different Diagnostic Criteria

The Journal of Allergy and Clinical Immunology. in Practice
Adam BarczykRafał Krenke

Abstract

The concordance between asthma-chronic obstructive pulmonary disease overlap (ACO) defined according to Global Inititative for Asthma (GINA)/Global Initiative for Chronic Obstructive Lung Disease (GOLD) and other diagnostic criteria is unknown. To assess the concordance between different ACO definitions and to estimate the definition-based ACO prevalence and characteristics. A prospective, real-life study based on a 32-item data set was performed in a mixed population of patients with asthma and chronic obstructive pulmonary disease (COPD). Five different definitions of ACO, including the GINA/GOLD criteria, were analyzed. A total of 1609 patients were included in the final analysis. Application of Venn diagram for ACO populations resulted in 31 ACO subpopulations, which were further reduced to 6 separate populations by introducing a rank order for the analyzed definitions to classify patients from intersecting groups. Overall, the level of agreement between different ACO definitions was poor. Cohen kappa coefficient for the agreement between ACO GINA/GOLD definition and other ACO definitions varied from 0.06 to 0.21. Only 2 patients (0.12%) met all the ACO definitions. Definition-based ACO prevalence ranged between 3.8% (Spani...Continue Reading

Citations

Dec 21, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Fanny W S Ko, David S C Hui
May 22, 2021·Annals of the American Thoracic Society·Antonios CharokoposJuan P Wisnivesky
Jun 19, 2021·The American Journal of Emergency Medicine·Michael W TsoulisAdam J Singer
Jun 25, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Miguel Roman-Rodriguez, Alan Kaplan
Jun 25, 2021·Journal of Asthma and Allergy·Karolina GórkaJerzy Soja
Jul 3, 2021·Diagnostics·Peter M A Calverley, Paul Phillip Walker

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