Asthma-COPD overlap is not a homogeneous disorder: further supporting data

Respiratory Research
Luis Pérez-de-LlanoCHACOS study group

Abstract

Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-α, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions.

References

Aug 11, 2012·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboRoberto Rodriguez-Roisin
May 2, 2014·Thorax·Alvar Agusti
Oct 24, 2015·The Lancet. Respiratory Medicine·Manali Mukherjee, Parameswaran Nair
Feb 29, 2016·Archivos de bronconeumología·Belen NúñezUNKNOWN Miembros del Grupo de Trabajo sobre la Caracterización Fenotípica y Evolución de la EPOC (PAC-COPD)
Jun 25, 2016·The European Respiratory Journal·Don D SinMichael E Wechsler
May 4, 2017·The European Respiratory Journal·Borja G CosíoUNKNOWN on behalf of the CHACOS study group
May 4, 2017·The European Respiratory Journal·Marc MiravitllesVicente Plaza

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Citations

Nov 22, 2018·Current Opinion in Pulmonary Medicine·Louis-Philippe Boulet, Nicola A Hanania
Nov 19, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Xinyu JiaMao Huang
Oct 20, 2018·Therapeutic Advances in Respiratory Disease·Borja G CosíoLuis Pérez de Llano
Sep 19, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Luis Pérez de LlanoBorja G Cosio
Aug 14, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Gulfidan Cakmak UzanBilun Gemicioglu
Feb 19, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Xiaofan TuPhilip M Hansbro
Apr 13, 2021·Archivos de bronconeumología·Marc MiravitllesJuan José Soler-Cataluña
Jul 3, 2021·Diagnostics·Peter M A Calverley, Paul Phillip Walker
Dec 1, 2019·Archivos de bronconeumología·Juan José Soler-CataluñaMarc Miravitlles
Oct 10, 2021·Chest·Clarus Leung, Don D Sin

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