Asthma from immune pathogenesis to precision medicine

Seminars in Immunology
Kareem KhalafEnrico Heffler

Abstract

Asthma is characterized by multiple immunological mechanisms (endotypes) determining variable clinical presentations (phenotypes). The identification of endotypic mechanisms is crucial to better characterize patients and to identify tailored therapeutic approaches with novel biological agents targeting specific immunological pathways. This review focused on summarizing the major immunological mechanisms involved in the pathogenesis of asthma, as well as on discussing the emergence of phenotypic features of the disease. Novel biological agents and other drugs targeting specific endotypes are discussed, as their use represent a precision medicine approach to the disease that is nowadays mandatory particularly for treating more severe patients.

Citations

Feb 27, 2020·Expert Review of Respiratory Medicine·Corrado PelaiaGirolamo Pelaia
Apr 30, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Corrado PelaiaNunzio Crimi
Dec 18, 2020·Frontiers in Immunology·Corrado PelaiaGirolamo Pelaia
Apr 2, 2021·Drug Design, Development and Therapy·Corrado PelaiaGirolamo Pelaia
Apr 15, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jingxi ZhangChong Bai
May 1, 2021·International Journal of Molecular Sciences·Corrado PelaiaAlessandro Vatrella
May 4, 2021·Frontiers in Immunology·Lucía Cremades-JimenoBlanca Cárdaba
Jul 2, 2021·Molecular Aspects of Medicine·Laura MaggiLorenzo Cosmi
Jun 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Corrado PelaiaGirolamo Pelaia

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