Asthma in COVID-19 patients: An extra chain fitting around the neck?

Respiratory Medicine
Mohammad H HusseinEmad Kandil

Abstract

The novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe. Pre-existing comorbidities have been found to have a dramatic effect on the disease course. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients. We conducted a multi-center retrospective study of positively confirmed COVID-19 patients. The primary outcome of interest was in-hospital mortality. Secondary outcomes were the Intensive Care Unit (ICU) admission, intubation, mechanical ventilation, and length of hospital stay. A total of 502 COVID-19 adult patients (72 asthma and 430 non-asthma cohorts) with mean age of 60.7 years were included in the study. The frequency of asthma in hospitalized cohorts was 14.3%. Univariate analysis revealed that asthma patients were more likely to be obese (75% versus 54.2%, p = 0.001), with a higher frequency of intubation (40.3% versus 27.8%, p = 0.036), and required a longer duration of hospitalization (15.1 ± 12.5 versus 11.5 ± 10.6, p = 0.015). After adjustment, multivariable analysis showed that asthmatic patients were not associated with higher risk of ICU admission (OR = 1.81, 95%CI = 0.98-3.09, p = 0.06), endotracheal intubation (OR = 1.77, 95%CI = 0.99-3....Continue Reading

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Citations

Jan 29, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Mohammad H HusseinEmad Kandil
Mar 25, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rakhee K RamakrishnanQutayba Hamid
Mar 28, 2021·Revue des maladies respiratoires·M UndernerN Jaafari
Jun 11, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Camille TailléCamille Couffignal
Jul 3, 2021·Journal of Community Hospital Internal Medicine Perspectives·Sridhar ChilimuriMuhammad Adrish

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