Asthma-like symptoms in young children increase the risk of COPD.

The Journal of Allergy and Clinical Immunology
Hans BisgaardKlaus Bønnelykke

Abstract

Chronic obstructive pulmonary disease (COPD) may originate in early life and share disease mechanisms with asthma-like symptoms in early childhood. This possibility remains unexplored on account of the lack of long-term prospective studies from infancy to the onset of COPD. We aimed to investigate the relationship between asthma-like symptoms in young children and development of COPD. In a population-based cohort of women who gave birth at the central hospital in Copenhagen during period from 1959 to 1961, we investigated data from 3290 mother-child pairs who attended examinations during pregnancy and when the children were aged 1, 3, and 6 years. COPD was assessed from the Danish national registries on hospitalizations and prescription medication since 1994. A subgroup of 930 individuals underwent spirometry testing at age 50 years. Of the 3290 children, 1 in 4 had a history of asthma-like symptoms in early childhood. The adjusted hazard ratio for hospitalization for COPD was 1.88 (95% CI = 1.32-2.68), and the odds ratio for prescription of long-acting muscarinic antagonists was 2.27 (95% CI = 1.38-3.70). Asthma-like symptoms in early childhood were also associated with a reduced FEV1 percent predicted and an FEV1-to-forced vi...Continue Reading

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Citations

Jun 20, 2021·Paediatric Respiratory Reviews·Andrew Bush
Sep 21, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Pengfei DuanQingying Zhang

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