PMID: 18713656Aug 21, 2008Paper

Asthma management and prevention: current perspectives

Clinical Cornerstone
Stuart W Stoloff

Abstract

The continuing evolution of asthma treatment and prevention are reflected in updated guidelines from the National Asthma Education and Prevention Program and Global Initiative for Asthma as well as other recent publications. The 2007 Expert Panel Report 3 guidelines designate severity and control, mediated by considerations of current impairment and future risk, as the primary concepts in assessing and monitoring asthma. Severity should ideally be determined at the time of diagnosis, after which control becomes the central focus of asthma management. In the area of treatment, inhaled corticosteroids (ICSs) remain first-line therapy for longterm asthma management in children and adults. For patients whose severity of asthma requires more than low-dose ICSs, or whose asthma cannot be well controlled on monotherapy with low-dose ICSs, evidence supports the efficacy of combination therapy consisting of an ICS plus an inhaled long-acting beta2-agonist (LABA) or an increase to medium-dose ICSs. For children >5 years of age and adults not controlled on low-dose ICSs, the combination of a low-dose ICS plus an inhaled LABA is equivalent in terms of outcomes to the use of medium-dose ICS. For children <5 years of age not controlled on lo...Continue Reading

References

Sep 10, 2004·The New England Journal of Medicine·Wayne J MorganUNKNOWN Inner-City Asthma Study Group
Apr 2, 2005·The European Respiratory Journal·H J A M SchönbergerC P van Schayck
Apr 15, 2006·American Journal of Respiratory and Critical Care Medicine·Mark HewKian Fan Chung
Jun 8, 2006·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Susana MarinhoAdnan Custovic
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar

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Citations

May 16, 2015·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Umran Cevik Guner, Ayda Celebioglu
Nov 30, 2018·Nature Reviews. Gastroenterology & Hepatology·Maxim S Petrov, Dhiraj Yadav

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