Asthma Phenotypes Defined From Parameters Obtained During Recovery From a Hospital-Treated Exacerbation

The Journal of Allergy and Clinical Immunology. in Practice
Rihuang QiuQingling Zhang

Abstract

Asthma is a heterogeneous disease with diverse clinical manifestations and inflammatory pathologies that is punctuated by exacerbations. To describe the clinical and inflammatory characteristics of patients with asthma treated in hospital for an acute exacerbation. Data from 320 adult patients receiving treatment for an acute exacerbation of asthma were obtained. In 218 patients with complete data, we used the Ward hierarchical clustering to obtain clusters. Pulmonary function, blood cell counts, sputum cell counts, serum IgE levels, and fractional exhaled nitric oxide were measured on hospital admission. We selected 13 variables with which we performed the Ward minimum-variance hierarchical clustering. Four clusters were defined. Clusters 1 (24.5%) and 3 (36.7%) were characterized by predominantly female patients with asthma with sputum neutrophilia, with cluster 1 associated with a small degree of airflow obstruction and early-onset asthma and cluster 3 with a moderate degree of reduction in FEV1. Clusters 2 (22.0%) and 4 (16.5%) were associated with high sputum eosinophilia and severe airflow obstruction. Cluster 4 was made exclusively of male smoking subjects, whereas cluster 2 was made up of predominantly female nonsmoking...Continue Reading

Citations

Oct 15, 2019·Frontiers in Immunology·Milena SokolowskaDieudonnée Togbe
Aug 26, 2020·Thorax·Matthew J MartinTim W Harrison
Oct 12, 2020·Allergy·Koichiro AsanoMasami Taniguchi
Jan 7, 2021·Allergy and Asthma Proceedings·Angelica Tiotiu
Oct 5, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Xin ZhangPeter Gerard Gibson
Feb 27, 2021·Thorax·Helena CrisfordJodie L Simpson
May 1, 2021·Diagnostics·Francisco CunhaJoão A Fonseca
Jun 29, 2021·The Lancet. Respiratory Medicine·Kian Fan Chung
Aug 5, 2021·Asthma Research and Practice·Ivana BanićMirjana Turkalj
Sep 19, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Clara E GreenAdel H Mansur

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