Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Si-Wei WangFeng Zhang

Abstract

Oxidative stress and inflammation are considered to be the main pathogenesis of cisplatin nephrotoxicity. Astilbin, a flavonoid with anti-oxidation and anti-inflammation function, has been used to treat heavy metal induced kidney injury. In this study, we investigated the protective effects of astilbin on cisplatin-induced nephrotoxicity and its underlying mechanisms. Our results showed that astilbin markedly inhibited cisplatin-induced cell apoptosis and recovered cell growth. Astilbin significantly decreased reactive oxygen species (ROS) accumulation and alleviated ROS-induced activation of p53, MAPKs and AKT signaling cascades, which in turn attenuated cisplatin-induced HEK-293 cell apoptosis. Astilbin effectively enhanced NRF2 activation and transcription of its targeting antioxidant genes to reduce ROS accumulation in cisplatin-induced HEK-293 cells. Furthermore, we found that astilbin obviously suppressed tumor necrosis factor alpha (TNF-α) expression and NF-κB activation, and also inhibited the expression of induced nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Finally, we confirmed that the effect of astilbin to improve renal oxidative stress and inflammation in cisplatin induced acute nephrotoxic mice. In ...Continue Reading

Citations

Jan 5, 2019·The Journal of Pharmacology and Experimental Therapeutics·Si-Wei WangFeng Zhang
Aug 27, 2019·Journal of Cellular and Molecular Medicine·Guangping LuXiaodong Song
Nov 5, 2019·Toxicology Mechanisms and Methods·Ibraheem M AttafiHesham M Korashy
Oct 12, 2019·Journal of Cellular and Molecular Medicine·Haiming JinJiake Xu
Jan 31, 2020·Oxidative Medicine and Cellular Longevity·Zhuqian WangDi Wang
May 24, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Akash AhujaaJae Youl Cho
Apr 30, 2020·The Journal of Pharmacy and Pharmacology·Meiyun ShiLei Yin
Jan 29, 2020·Antioxidants & Redox Signaling·Katarína SmolkováPéter Bai
Jun 23, 2019·International Journal of Molecular Sciences·Sara J HolditchCharles L Edelstein
Mar 27, 2020·Neural Regeneration Research·Andrijana LazicMilena Stevanović
Mar 16, 2019·Cellular and Molecular Neurobiology·Jelena PopovićGayle E Woloschak
Sep 20, 2019·Journal of Inorganic Biochemistry·Fan DuYun-Jun Liu
Aug 10, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Mohammad Amin DehghaniMasoud Mahdavinia
Mar 6, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Si-Wei WangFeng Zhang
Mar 6, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Si-Wei WangFeng Zhang
Apr 2, 2021·Drug Development Research·Moein AlaAhmad Reza Dehpour
May 15, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chen GaoZhihui Hao
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yemin XuBin Deng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis