Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund's Adjuvant-Induced Arthritis Rats

Evidence-based Complementary and Alternative Medicine : ECAM
Lisha DongXiaoyu Chen

Abstract

Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb. (with red cross-section) grown in Guizhou Province, China. We accessed its effect and potential mechanism on attenuation of the inflammatory response in CFA-induced AA rats. Our results showed that daily oral administration of astilbin at 5.3 mg/kg reduced joint damage in the hind paw of AA rats. Accordingly, astilbin exhibited remarkable inhibitory effects on TNF-α, IL-1β, and IL-6 mRNA expression. Significant decrease of serum cytokine levels of TNF-α, IL-1β, and IL-6 was also observed in astilbin-treated AA rats compared to the vehicle-treated AA rats. The reduced expression of these cytokines was associated with protein activity suppression of three key molecular targets in the pathogenesis of RA, including IKKβ, NF-κB p65 subunit, and TLR adaptor MyD88. Furthermore, the therapeutic effects of astilbin on the inhibition of cytokines production as well as the reduction of inflammatory response in AA rats are close to a commonly used antirheumatic drug, leflunomide. Collectively, our data suggest that the action mechanism of astilbin, as an anti-inflammatory agent for RA treatment, is associated with modulating the production of proinflammato...Continue Reading

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Citations

Oct 12, 2019·Journal of Cellular and Molecular Medicine·Haiming JinJiake Xu
Jan 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Lisha DongXiaoyu Chen
Apr 30, 2020·The Journal of Pharmacy and Pharmacology·Meiyun ShiLei Yin
Jun 27, 2020·BMC Complementary Medicine and Therapies·Bishnu Prasad PandeySaroj Nepal

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Methods Mentioned

BETA
X-ray
PCR
ELISA
electrophoresis
Assay

Software Mentioned

SPSS
ImageJ

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