Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

Advances in Pharmacological Sciences
Ammara RiazZeliha Selamoglu

Abstract

Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-κB, TNF-α, and TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1α, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLCγ1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IκBα, PI3K, and PKCβ2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1β, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-...Continue Reading

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Citations

Oct 12, 2019·Journal of the Science of Food and Agriculture·Fernanda F JulianoSeverino M Alencar
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fernanda Mendes RezendeClaudia Maria Furlan
Jul 4, 2020·Oxidative Medicine and Cellular Longevity·Faris AlrumaihiMasood Alam Khan
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae Sik YuKi Hyun Kim
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia KłeczekAnna Stojakowska
Feb 13, 2021·Antioxidants·Maria-Luisa Pérez-LozanoHechmi Toumi
Mar 23, 2021·BioMed Research International·Shaymaa Fadhel Abbas AlbaayitMohd Hezmee Mohd Noor
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sojeong KimSang-Jip Nam
Sep 26, 2020·Current Topics in Medicinal Chemistry·Chen XuBan-Feng Ruan
Aug 17, 2021·Chemical Biology & Drug Design·Zhongqing WangQing Lin

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Methods Mentioned

BETA
glycosylation
nuclear translocation
bronchoalveolar lavage

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