Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes

Frontiers in Pharmacology
Qingyun JiaQianqian Liang

Abstract

Astragalin, as a bioactive flavonoid with anti-inflammatory, antioxidant, and protective properties, provides a potential agent for rheumatoid arthritis (RA). In this study, its therapeutic efficacy and the underlying mechanisms were explored using DBA/1J mice with collagen-induced arthritis (CIA). It was demonstrated that astragalin could significantly attenuate inflammation of CIA mice. The effects were associated with decreased severity of arthritis (based on the arthritis index), joint swelling and reduced bone erosion and destruction. Furthermore, astragalin treatment suppressed the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8), and inhibited the expression of matrix metalloproteinases (MMP-1, MMP-3, and MMP-13) in chondrocytes and synovial cells of CIA mice. Fibroblast-like synoviocytes derived from RA patients (MH7A cells) were applied to verify these effects. In vitro, astragalin inhibited the expression of matrix metalloproteinases (MMP-1, MMP-3, and MMP-13) dose-dependently in TNF-α-induced MH7A cells, with no apparent cytotoxicity. Furthermore, astragalin suppressed the phosphorylation of p38, JNK, and the activation of c-Jun/AP-1 in TNF-α-induced MH7A cells. In conclusion, it has proven tha...Continue Reading

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Citations

Feb 13, 2021·Antioxidants·Maria-Luisa Pérez-LozanoHechmi Toumi
Mar 23, 2021·BioMed Research International·Liying WuZhiguang Yao
Apr 6, 2021·Journal of Orthopaedic Translation·Jianhai ChenPeng Zhang
Aug 3, 2021·Experimental and Therapeutic Medicine·Jing LuanXingchun Gou
May 13, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chuanmei XieZhenyi Zhao
Dec 28, 2021·Critical Reviews in Food Science and Nutrition·A S M Ali RezaEduardo Sobarzo-Sánchez

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Methods Mentioned

BETA
ELISA
X-ray
PCR

Software Mentioned

ImageJ
SCANCO
Vevo LAB
GraphPad Prism

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