Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy

Archives of Biochemistry and Biophysics
Weijie WenMin Li

Abstract

Astragalus membranaceus is a fundamental herb in Traditional Chinese Medicine and has attracted significant attention due to its anti-inflammatory, and longevity effects. However, its anti-photoaging property remains to be defined. Autophagy plays important roles in regulating cell homeostasis and aging processes. Whether regulation of autophagy could be an efficient way for anti-photoaging is still unclear. To investigate the effects and the possible mechanism of astragaloside on anti-photoaging in UVB-induced photoaging cell model. Primary rat dermal fibroblasts were prepared by repeated exposures to UVB irradiation. The expression levels of cytokines and signal molecules were determined by RT-PCR and western blot. SA-β-gal staining was performed to indicate senescence level. Intracellular reactive oxygen species and mitochondrial membrane potential were monitored by fluorescent probes DCFH-DA and JC-1. The cell viability was determined using Cell Counting Kit-8. Astragaloside increases the expression of collagen-I (Col1) downregulated by UVB. UVB-induced oxidative stress and photoaging could be inhibited by astragaloside. The degradation of Col1 caused by UVB irradiation through activated ERK and p38 signals could be suppres...Continue Reading

Citations

Apr 20, 2019·International Journal of Molecular Sciences·Hao ShanMin Li
May 16, 2020·The Journal of Pharmacy and Pharmacology·Xin LiuBaoping Shao
Apr 8, 2020·Journal of Neuroinflammation·Mei-Ling XiaGang Hu
Jun 13, 2020·BMC Complementary Medicine and Therapies·Hongjie WangSiyun Niu
Dec 17, 2020·Phytotherapy Research : PTR·Bahare SalehiCarmen Sadaka
Apr 25, 2021·Journal of Cosmetic Dermatology·Jie WangYuehua Yan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms