Astragaloside Inhibits Hepatic Fibrosis by Modulation of TGF-β 1/Smad Signaling Pathway

Evidence-based Complementary and Alternative Medicine : ECAM
Xingxing YuanYali Zhang

Abstract

Activation of HSC is a pivotal step in hepatic fibrosis. In the activation of HSC, the TGF-β1 plays a key role that can promote the occurrence of hepatic fibrosis by combining with Smad proteins. Astragaloside is the main active component extracted from Radix Astragali that has the effect of antioxidation and hepatoprotection. In the present study, we investigated the mechanism of astragalosides inhibiting hepatic fibrosis in vitro and in vivo. In vitro, astragalosides inhibited the activation of HSC and regulated the expression of MMP-2 and TIMP-2 and reduced the formation of collagen fibers. In vivo, administration of astragalosides decreased the serum ALT, AST, and TBiL in rats by reducing oxidative stress. Astragalosides also attenuated hepatic fibrosis by reducing the concentration of hydroxyproline and inhibiting the formation of collagen fibers. The expressions of TGF-β1, TβR-I, p-Smad 2, and p-Smad 3 were downregulated after astragalosides treatments, while Smad 7 was upregulated compared to the control group. The results indicated that the effect of astragaloside on hepatic fibrosis was related to the inhibition of HSC activation and the modulation of the TGF-β1/Smad signaling pathway.

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Citations

Nov 7, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Bo YangFeng Zhang
Dec 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Peng-Chun YangShi-Zhu Jiang
Jul 10, 2021·World Journal of Gastroenterology : WJG·Qiu-Ju HanJian Zhang

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