Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Guang-Xiao NiYa-Li Wang

Abstract

Astragaloside IV (AST) as the main active ingredient of Astragalus membranaceus. Clinical and laboratory-based studies have demonstrated the effects of AST on cerebral protection and angiogenesis after ischemia stroke. In addition, several reports investigated the effect of AST on proliferation of neural stem cells. The current study was aimed to evaluate the influence of AST on neurogenesis in hippocampal dentate gyrus (DG) of MCAO rats and to explore the possible mechanisms. In this study, the neurobehavioral tests (Ludmila Belayev 12-point scoring, Screen test, fore limb placing test) had been employed to investigate the effect of AST treatment against functional deficit of MCAO rats. The immunofluorescence staining, western-blot and qRT-PCR was performed to evaluate the effects of AST on proliferation, differentiation and maturity of neural stemr cells in hippocampus. Moreover, we investigated the possible mechanism of the AST treatment in promoting neurogenesis after ischemic stroke. The findings indicated that AST treatment ameliorated the neurobehavior of MCAO rats. The results indicated that AST treatment possessed the potential to improve proprioceptive sense and motor function of MCAO rats. AST treatment sustained neu...Continue Reading

References

Jan 1, 1992·Neuroscience·B E Reese, R J Colello
Jan 1, 1992·Experimental Neurology·A Alvarez-Buylla
Aug 31, 1990·Biochemical and Biophysical Research Communications·L H ElliottJ S Nixon
Mar 18, 2006·Neuroreport·Makoto TamuraMaki K Yamada
Dec 19, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Tzong-Shiue YuSteven G Kernie
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
Sep 26, 2015·Nature Communications·Jennifer C Kasemeier-KulesaPaul M Kulesa
Mar 19, 2016·Translational Stroke Research·Seong-Ho Koh, Hyun-Hee Park
Mar 18, 2017·Oxidative Medicine and Cellular Longevity·Hui-Lin WangGuo-Qing Zheng
Aug 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·Russell W ChanEd X Wu
Apr 4, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert M DietzPaco S Herson
Apr 7, 2018·Cell Stem Cell·Maura BoldriniJ John Mann
Jun 17, 2018·Annals of Neurology·Theodor Rüber, Gottfried Schlaug
Feb 23, 2019·Folia Neuropathologica·Tomasz StępieńTeresa Wierzba-Bobrowicz
Mar 18, 2019·Lancet Neurology·Simiao WuUNKNOWN China Stroke Study Collaboration

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.