Astragaloside IV improves the isoproterenol-induced vascular dysfunction via attenuating eNOS uncoupling-mediated oxidative stress and inhibiting ROS-NF-κB pathways

International Immunopharmacology
Chonghua XuHongxin Wang

Abstract

Oxidative stress and inflammation are regarded as two important triggers of endothelial dysfunction and play pivotal role in progression of vascular damage associated with cardiac hypertrophy. Our previous studies demonstrated that astragaloside IV (AsIV) could protect against cardiac hypertrophy in rats induced by isoproterenol (Iso), but its effects on the aorta are not known. In present study, we aimed to assess the effects of AsIV on Isoinduced vascular dysfunction. Sprague-Dawley (SD) rats were treated with Iso (10mg/kg/d) alone or in combination with AsIV (50mg/kg/d). Compared with Isotreated alone, AsIV significantly reduced the ratios of heart weight/body weight and left ventricular weight/body weight. AsIV ameliorated the increased vasoconstriction response to phenylephrine induced by Iso and suppressed superoxide anion generation in rat aorta, increased endothelial nitric oxide synthase (eNOS) dimer/monomer ratio and its critical cofactor tetrahydrobiopterin (BH4) content in aorta as well as the NO production in the serum, reduced the plasmatic peroxynitrite (ONOO-). Moreover, in contrast with Isotreatment alone, AsIV decreased the ratio of nuclear-to-cytosolic protein expression of the NF-κB p65 subunit while enhance...Continue Reading

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Citations

Jan 18, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Lingjing TanSongbai Yang
Aug 28, 2020·Frontiers in Physiology·Moises Freitas-AndradeBaptiste Lacoste
Sep 29, 2020·Drug Design, Development and Therapy·Yu-Qing TanJun Li
Jan 9, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xueyi ChenZhice Xu
Feb 3, 2021·International Journal of Molecular Sciences·Yue RuanAdrian Gericke
Sep 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qingqing ChenWeiping Li

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