Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-κB/PGC-1α signaling mediated energy biosynthesis

PloS One
Suping ZhangHongxin Wang

Abstract

We previously reported that Astragaloside IV (ASIV), a major active constituent of Astragalus membranaceus (Fisch) Bge protects against cardiac hypertrophy in rats induced by isoproterenol (Iso), however the mechanism underlying the protection remains unknown. Dysfunction of cardiac energy biosynthesis contributes to the hypertrophy and Nuclear Factor κB (NF-κB)/Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α) signaling gets involved in the dysfunction. The present study was designed to investigate the mechanism by which ASIV improves the cardiac hypertrophy with focuses on the NF-κB/PGC-1α signaling mediated energy biosynthesis. Sprague-Dawley (SD) rats or Neonatal Rat Ventricular Myocytes (NRVMs) were treated with Iso alone or in combination with ASIV. The results showed that combination with ASIV significantly attenuated the pathological changes, reduced the ratios of heart weight/body weight and Left ventricular weight/body weight, improved the cardiac hemodynamics, down-regulated mRNA expression of Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP), increased the ratio of ATP/AMP, and decreased the content of Free Fat Acid (FFA) in heart tissue of rats compared with Iso alone. In addit...Continue Reading

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Citations

Jan 24, 2018·World Journal of Gastroenterology : WJG·Zhen-Fei WangHai-Wen Lu
Sep 6, 2019·Cardiovascular Toxicology·Nasiruddin NalbanRamakrishna Sistla
Sep 29, 2020·Drug Design, Development and Therapy·Yu-Qing TanJun Li
Jan 20, 2021·Medicinal Research Reviews·Hui-Fei SuXue Qiao
Oct 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Li ZhuGuoan Zhao

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Methods Mentioned

BETA
Enzyme-linked immunosorbent assay

Software Mentioned

Quantity One
LAS
AcqKnowledge
SPSS

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