Astragalus Polysaccharides Attenuate Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

The American Journal of Chinese Medicine
Lin-Bo YuanQing-Hua Hu

Abstract

Astragalus polysaccharides (APS) have been shown to possess a variety of biological activities including anti-oxidant and anti-inflammation functions in a number of diseases. However, their function in pulmonary arterial hypertension (PAH) is still unknown. Rats received APS (200[Formula: see text]mg/kg once two days) for 2 weeks after being injected with monocrotaline (MCT; 60[Formula: see text]mg/kg). The pulmonary hemodynamic index, right ventricular hypertrophy, and lung morphological features of the rat models were examined, as well as the NO/eNOS ratio of wet lung and dry lung weight and MPO. A qRT-PCR and p-I[Formula: see text]B was used to assess IL-1[Formula: see text], IL-6 and TNF-[Formula: see text] and WB was used to detect the total I[Formula: see text]B. Based on these measurements, it was found that APS reversed the MCT-induced increase in mean pulmonary arterial pressure (mPAP) (from 32.731[Formula: see text]mmHg to 26.707[Formula: see text]mmHg), decreased pulmonary vascular resistance (PVR) (from 289.021[Formula: see text]mmHg[Formula: see text][Formula: see text] min/L to 246.351[Formula: see text]mmHg[Formula: see text][Formula: see text][Formula: see text]min/L), and reduced right ventricular hypertrophy (...Continue Reading

References

Sep 22, 2000·The Journal of Biological Chemistry·E BourkeP N Moynagh
Jul 27, 2001·Transplantation·A ArdehaliP F Waters
Sep 4, 2003·The European Respiratory Journal·P DorfmüllerM Humbert
Aug 11, 2004·Cardiology Clinics·Norbert F Voelkel, Carlyne Cool
Oct 2, 2004·The New England Journal of Medicine·Marc HumbertGérald Simonneau
Dec 24, 2005·The New England Journal of Medicine·Mark J D Griffiths, Timothy W Evans
Aug 18, 2006·American Journal of Physiology. Cell Physiology·Brian S ZuckerbraunEdith Tzeng
Sep 27, 2006·Handbook of Experimental Pharmacology·S Moncada, E A Higgs
Nov 21, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Phil BothaSteven C Clark
Jul 16, 2013·Journal of the American College of Cardiology·Nazzareno Galiè, Alessandra Manes
Sep 21, 2013·Current Opinion in Pulmonary Medicine·Adriano R Tonelli
Oct 16, 2013·Biological Chemistry·Jérôme LugrinLucas Liaudet
Dec 21, 2013·Journal of the American College of Cardiology·Marius M HoeperDavid B Badesch
Apr 18, 2014·Respiratory Research·Alexandra GrothLars C Huber
Jun 22, 2014·Circulation Research·Marlene RabinovitchMark R Nicolls
Oct 17, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Naveen K SomannaReza Izadpanah
Nov 12, 2014·Circulation·Jonathan D Rich, Stuart Rich
Feb 12, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tao LuoLimin Zheng
Mar 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi KameshimaHideyuki Yamawaki
Mar 20, 2015·The American Journal of Chinese Medicine·Yuliang WangBaoshan Liu
Mar 20, 2015·The American Journal of Chinese Medicine·Kun-Cheng LiYuan-Shiun Chang
May 9, 2015·Journal of the American College of Cardiology·Vallerie V McLaughlinMarc Humbert
May 12, 2015·Mediators of Inflammation·Wei-Jian Zhang, Balz Frei
Oct 16, 2015·Critical Reviews in Food Science and Nutrition·Jian-Hua XieMing-Yong Xie
Dec 2, 2015·The American Journal of Chinese Medicine·Chien-Kuo HanYuan-Li Huang
Feb 27, 2016·The American Journal of Chinese Medicine·Kathy K AuyeungJoshua K Ko
Feb 27, 2016·The American Journal of Chinese Medicine·Yu-Lan YehChih-Yang Huang
Apr 26, 2016·The American Journal of Chinese Medicine·Yue WangKathy Kawai Auyeung
Apr 26, 2016·The American Journal of Chinese Medicine·Rui JiaoKwok Fai So
May 26, 2016·The American Journal of Chinese Medicine·Jingyun ShaoMingwei Chen

❮ Previous
Next ❯

Citations

Oct 30, 2019·Current Drug Delivery·Jiandong YuYang Xiong
Aug 17, 2019·Current Vascular Pharmacology·Hoa Thi PhuGianfranco Pintus
Apr 9, 2020·Frontiers in Pharmacology·Yijun ZhengYongqi Liu
Apr 1, 2020·Frontiers in Pharmacology·Seyed Vahid JasemiJavier Echeverría
Aug 28, 2021·Experimental and Therapeutic Medicine·Juan LiuXiaozhi Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.