Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas?

OncoTargets and Therapy
Marta MellaiDavide Schiffer

Abstract

The diagnosis of astroblastoma is based on a typical histological aspect with perivascular distribution of cells sending cytoplasmic extensions to the vessels and vascular hyalinization. These criteria are useful for standardizing the identification of the tumor, but, in spite of this, there are discrepancies in the literature concerning the age distribution and the benign or malignant nature of the tumor. Three cases are discussed in this study: Case 1 was a typical high-grade astroblastoma; Case 2 was an oligodendroglioma at the first intervention and an oligoastrocytoma at the second intervention with typical perivascular arrangements in the astrocytic component; Case 3 was a gemistocytic glioma with malignant features and typical perivascular arrangements. Genetic analysis showed genetic alterations that are typical of gliomas of all malignancy grades. Using the neurosphere assay, neurospheres and adherent cells were found to have developed in Case 1, while adherent cells only developed in Case 2, in line with the stemness potential of the tumors. The cases are discussed in relation to their diagnostic assessment as astroblastoma, and it is hypothesized that the typical perivascular distribution of cells may not indicate a ...Continue Reading

Citations

Jul 19, 2016·Cancer Genetics·Tejus A BaleKeith L Ligon
Dec 19, 2017·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O I KitS B Panina
Jun 18, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Riccardo BernasconiValeria Barresi
May 10, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Supriya MallickGoura K Rath
Apr 22, 2018·Journal of Medical Case Reports·Nawal HammasLaila Chbani
Feb 4, 2021·Neuropathology and Applied Neurobiology·Karan R ChaddaUNKNOWN Genomics England Research Consortium
Nov 25, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ryo KurokawaToshio Moritani

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Methods Mentioned

BETA
electron microscopy
electrophoresis
PCR
confocal microscopy

Software Mentioned

GeneMapper
Sequencing Analysis

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