Astrocyte and microglial control of glutamatergic signalling: a primer on understanding the disruptive role of chronic stress

Journal of Neuroendocrinology
J MayhewF R Walker

Abstract

It is now well established that chronic stress can induce significant structural remodelling of astrocytes and microglia. Until recently, however, the full significance of these morphological disturbances has remained unclear. Clues to the significance of astroglial re-organisation following stress are beginning to emerge from a compelling literature describing how astrocytes contribute to glutamatergic neurotransmission. The present review briefly summarises these two fields of research, identifies points of overlap and, in doing so, pin-points future research directions for stress neurobiology. Ultimately, understanding how chronic stress can disrupt the interactions of astrocytes and microglia with neurones has the potential in the future to improve the development of therapeutics designed to treat stress-related illnesses such as depression.

References

Jan 1, 1990·Annual Review of Neuroscience·D W Choi, S M Rothman
Jul 1, 1987·Behavioral and Neural Biology·M R FoyR F Thompson
Jun 30, 1994·Nature·V ParpuraP G Haydon
Feb 5, 1999·Glia·D R Brown, C M Mohn
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
May 20, 1999·Biological Psychiatry·G RajkowskaC A Stockmeier
Apr 3, 2001·Journal of Neuroimmunology·M A WollmerR Mentlein
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Verderio, M Matteoli
Jul 5, 2001·Neuroscience Letters·K NakajimaT Kurihara
Sep 29, 2001·Brain Research Bulletin·D R CotterI P Everall
Jan 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carola G SchipkeHelmut Kettenmann
May 10, 2002·Hippocampus·Constantine PavlidesBruce S McEwen
Jun 18, 2002·Journal of Neurochemistry·Beáta SperlághE Sylvester Vizi
Sep 21, 2002·Biological Psychiatry·Michael P BowleyJoseph L Price
Oct 25, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·S DavisJ T O'Brien
May 20, 2003·The European Journal of Neuroscience·Deborah N AlfarezHarm J Krugers
May 29, 2003·Journal of Neuropathology and Experimental Neurology·Anne Valérie Vallat-DecouvelaereFrançoise Gray
Jan 15, 2004·The Journal of Biological Chemistry·Qi ZhangPhilip G Haydon
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Todd A Fiacco, Ken D McCarthy
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lawrence P ReaganBruce S McEwen
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vedrana MontanaVladimir Parpura
Jun 24, 2004·Brain Research. Brain Research Reviews·Yasushi ShigeriKeiko Shimamoto
Jul 9, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohong SiGrazyna Rajkowska
Aug 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·María Cecilia AnguloEtienne Audinat
Sep 30, 2004·Neurochemical Research·Fernanda Urruth FontellaCarla Dalmaz
Nov 13, 2004·Journal of Neuropathology and Experimental Neurology·Fabrice ChrétienGabriel Gras
Dec 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne RoumierAlain Bessis

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Citations

Feb 7, 2016·Brain, Behavior, and Immunity·Katelyn N RobillardAndrew G MacLean
Jan 23, 2016·Psychoneuroendocrinology·Laura K FonkenSteven F Maier
Dec 29, 2015·Journal of Neurochemistry·Gaëlle Champeil-PotokarIsabelle Denis
Aug 2, 2015·Brain, Behavior, and Immunity·Giampaolo MiliorLaura Maggi
Oct 4, 2017·The International Journal of Neuroscience·Yan-Na LianYing Zhang
Jul 2, 2020·Stress : the International Journal on the Biology of Stress·Janine M SimmonsJoshua A Gordon
Jun 17, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephanie SimardNatalina Salmaso
Jul 18, 2018·Metabolic Brain Disease·Yanjie QinYongning Lu
Jul 24, 2020·Molecular Neurobiology·Leszek Rudzki, Michael Maes
Feb 16, 2021·Neurochemistry International·Katherine PicardMarie-Ève Tremblay
Dec 27, 2018·Neuroscience Letters·Vitor Rocco TorrezLuis Valmor Portela
Oct 2, 2021·European Archives of Psychiatry and Clinical Neuroscience·Ralf BrischRainer Wolf

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