Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System.

Cells
Erik NutmaLaura A N Peferoen

Abstract

Over the last decade knowledge of the role of astrocytes in central nervous system (CNS) neuroinflammatory diseases has changed dramatically. Rather than playing a merely passive role in response to damage it is clear that astrocytes actively maintain CNS homeostasis by influencing pH, ion and water balance, the plasticity of neurotransmitters and synapses, cerebral blood flow, and are important immune cells. During disease astrocytes become reactive and hypertrophic, a response that was long considered to be pathogenic. However, recent studies reveal that astrocytes also have a strong tissue regenerative role. Whilst most astrocyte research focuses on modulating neuronal function and synaptic transmission little is known about the cross-talk between astrocytes and oligodendrocytes, the myelinating cells of the CNS. This communication occurs via direct cell-cell contact as well as via secreted cytokines, chemokines, exosomes, and signalling molecules. Additionally, this cross-talk is important for glial development, triggering disease onset and progression, as well as stimulating regeneration and repair. Its critical role in homeostasis is most evident when this communication fails. Here, we review emerging evidence of astrocyt...Continue Reading

References

Jan 1, 1988·Annals of the New York Academy of Sciences·K Selmaj, C S Raine
Aug 1, 1989·The Journal of Experimental Medicine·F M HofmanJ E Merrill
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F A McMorrisR W Furlanetto
Jun 1, 1985·Brain : a Journal of Neurology·D Borrett, L E Becker
Jul 23, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·R MesquitaM M de Siqueira
Jan 29, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B Durand, M Raff
Feb 24, 2001·Journal of Molecular Neuroscience : MN·F M LaFerlaM A Leissring
Apr 12, 2001·Journal of Neurochemistry·A JeremicS Jeftinija
Jul 5, 2001·Neuropathology and Applied Neurobiology·S H GoldbergE Lavi
Sep 25, 2002·Journal of Neuroscience Research·Anuska V AndjelkovicJoel S Pachter
Oct 29, 2002·Developmental Neuroscience·Daniel J Morath, Margot Mayer-Pröschel
Feb 25, 2003·The Journal of Infectious Diseases·Thomas KossmannPhillip D Smith
Jul 20, 2004·Nature Medicine·Xiaohai WangMaiken Nedergaard
Jul 28, 2004·Molecular and Cellular Neurosciences·Jill SeeJudith B Grinspan
Feb 9, 2005·Experimental Neurology·Arthur M Butt, Jennifer Dinsdale
Jun 11, 2005·The New England Journal of Medicine·Annette Langer-GouldDaniel Pelletier
Aug 9, 2005·Glia·Kakuri M OmariCedric S Raine
Feb 24, 2006·Nature Reviews. Neuroscience·Gerald SeifertChristian Steinhäuser
Feb 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roumen BalabanovBrian Popko
Mar 9, 2007·Molecular and Cellular Neurosciences·Jennifer L Orthmann-MurphySteven S Scherer
May 8, 2007·Neuron·Freda D Miller, Andrée S Gauthier
Aug 31, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlos MatuteMaría Domercq
Sep 15, 2007·Journal of Neurochemistry·Jack van HorssenHelga E de Vries
Feb 1, 2008·Journal of Molecular Neuroscience : MN·Jennifer L Orthmann-MurphySteven S Scherer
Jul 1, 2008·Neurobiology of Aging·J E SimpsonUNKNOWN MRC Cognitive Function and Ageing Neuropathology Study Group
Jul 23, 2008·Journal of Neurochemistry·Dana M McTigue, Richa B Tripathi
Nov 14, 2008·Journal of Biosciences·Pankaj Seth, Nitin Koul
Feb 21, 2009·Nature Reviews. Neuroscience·Asya RollsMichal Schwartz
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roberta BrambillaJohn R Bethea
Aug 4, 2009·Mechanisms of Ageing and Development·Karen M WeidenheimIsabelle Rapin
Aug 8, 2009·Molecular and Cellular Neurosciences·Jun-Ping LiuHe Li
Aug 27, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Akiyuki UzawaSatoshi Kuwabara
Sep 22, 2010·Journal of Neuroscience Research·Craig S MooreStephen J Crocker
Oct 15, 2010·Journal of Neuroinflammation·Bridgette D SempleM Cristina Morganti-Kossmann
Nov 12, 2010·Nature·David H Rowitch, Arnold R Kriegstein
Jan 18, 2011·Trends in Neurosciences·Igor AllamanPierre J Magistretti

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Citations

Jun 18, 2020·International Journal of Molecular Sciences·Kim M A De Kleijn, Gerard J M Martens
Oct 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dusica MaysingerAshok Kakkar
Jan 5, 2021·Frontiers in Neuroscience·Hui WangAi-Min Wu
Jan 20, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sandrine Bourgeois-TardifAlexander G Weil
Dec 18, 2020·Frontiers in Cellular Neuroscience·Dieuwke Maria de Waard, Marianna Bugiani
Mar 28, 2021·Acta Pharmacologica Sinica·Hong-Yun WangNai-Hong Chen
May 11, 2021·Frontiers in Cellular Neuroscience·Anoushka LotunGuangping Gao
May 5, 2021·Developmental Neurobiology·Foluwasomi A OyefesoMichael J Pecaut
May 25, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lin CongBin Xu
Jul 10, 2021·Frontiers in Cellular Neuroscience·Georg von JonquieresGary D Housley
Jul 17, 2021·Frontiers in Cellular Neuroscience·Judith LeyhKarsten Winter
Oct 20, 2020·Progress in Retinal and Eye Research·Christophe BaudouinElisabeth M Messmer
Oct 15, 2020·Journal of Neuroinflammation·Chiara BurgalettoGiuseppina Cantarella
Sep 4, 2021·Experimental and Therapeutic Medicine·Wei ZengHongfang Xu

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