Astrocyte-derived growth factor (S100 beta) and motor function in rats following cardiac arrest

Pharmacology, Biochemistry, and Behavior
S P JawD D Truong

Abstract

Following 10-min cardiac arrest and resuscitation, the central serotonergic system and motor function of rats were found to be affected and later on restored. Astrocyte-derived growth factor (S100 beta) is known to promote survival and neurite outgrowth of serotonergic neurons. In the present study, brain levels of S100 beta were investigated with quantitative immunoblot analysis at various time points following cardiac arrest. Significant reductions of S100 beta were found in the cerebral cortex (30%), midbrain (35%), and cerebellum (46%) of rats 3 days postcardiac arrest. In contrast, at 14 and > 45 days, significant increases of S100 beta were detected in the cerebral cortex (57%; 81%), midbrain (70%; 97%), and cerebellum (84%; 157%). The results indicate that reactive astrocytosis and elevated levels of S100 beta may participate in the recovery processes following hypoxic-ischemic insults to the brain.

References

May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H SelinfreundL J Van Eldik
May 21, 1990·Brain Research·E C AzmitiaP M Whitaker-Azmitia
Nov 14, 1984·Biochemical and Biophysical Research Communications·L J Van Eldik, S R Wolchok
Apr 1, 1995·Pharmacology, Biochemistry, and Behavior·R R MatsumotoD D Truong
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·S P JawD D Truong
Mar 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·D D TruongC G Wasterlain
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·S P JawD D Truong

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Citations

Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·S P JawD D Truong
Jan 1, 1996·Brain Research Bulletin·S P JawM Nguyen
Feb 17, 2000·Brain Research. Developmental Brain Research·S C TiuD T Yew

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