Astrocyte-derived lipoxygenase product evokes endothelium-dependent relaxation of the basilar artery

Journal of Neuroscience Research
S MurphyF M Faraci

Abstract

The goal of this study was to examine the possible production of vasoactive factors by astrocytes. We consistently observe that rat astroglial cells in suspension produce marked relaxation when added to precontracted rings of intact (but not endothelium-denuded) rabbit basilar artery. The ultimate mediator of this relaxation was endothelium-derived nitric oxide whose synthesis is activated by an as yet unidentified factor(s) produced tonically by astrocytes. The factor is relatively stable, and is not arachidonate, or a product of cyclooxygenase or P450 metabolism. Based upon studies with selective inhibitors, the factor appears to result from 12- or 15-lipoxygenase metabolism, the products of which are known to be vasoactive. In a separate series of experiments, astrocyte-conditioned medium stimulated the production of citrulline from L-arginine by nitric oxide synthase in bovine aortic endothelial cells. The possible significance for central nervous system (CNS) pathophysiology of an astrocyte-derived vasodilator is discussed.

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Citations

Feb 18, 2004·Thrombosis Research·Jeong Ai KimMark J Fisher
Dec 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N D TranM Fisher
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·J E BrianD D Heistad
Feb 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Frank M Faraci
Mar 1, 1994·Stroke; a Journal of Cerebral Circulation·F M Faraci, J E Brian
Feb 23, 2019·The European Journal of Neuroscience·Mariam CharkvianiDavid Lominadze
Apr 22, 2004·Nature Reviews. Neuroscience·Costantino Iadecola
Dec 17, 2005·Journal of Applied Physiology·Jon AndresenRobert M Bryan
Feb 10, 2006·Journal of Applied Physiology·Edith Hamel
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Dec 1, 2004·Journal of Neurochemistry·M ChisariM A Sortino

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