Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America
Luni EmdadPaul B Fisher

Abstract

Astrocyte-elevated gene-1 (AEG-1) expression is increased in multiple cancers and plays a central role in Ha-ras-mediated oncogenesis through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Additionally, overexpression of AEG-1 protects primary and transformed human and rat cells from serum starvation-induced apoptosis through activation of PI3K/Akt signaling. These findings suggest, but do not prove, that AEG-1 may function as an oncogene. We now provide definitive evidence that AEG-1 is indeed a transforming oncogene and show that stable expression of AEG-1 in normal immortal cloned rat embryo fibroblast (CREF) cells induces morphological transformation and enhances invasion and anchorage-independent growth in soft agar, two fundamental biological events associated with cellular transformation. Additionally, AEG-1-expressing CREF clones form aggressive tumors in nude mice. Immunohistochemistry analysis of tumor sections demonstrates that AEG-1-expressing tumors have increased microvessel density throughout the entire tumor sections. Overexpression of AEG-1 increases expression of molecular markers of angiogenesis, including angiopoietin-1, matrix metalloprotease-2, and hypoxia-inducible factor 1-alpha. In vitr...Continue Reading

References

Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L E BabissP B Fisher
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P B FisherH S Ginsberg
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z Z SuP B Fisher
May 20, 1998·Current Biology : CB·T I KoblizekW Risau
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·P LinK G Peters
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z Z SuP B Fisher
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 29, 2000·The Journal of Biological Chemistry·A PapapetropoulosW C Sessa
Mar 31, 2000·Nature Medicine·P Carmeliet
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·A PfeiferI M Verma
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shinji TanakaKeizo Sugimachi
Apr 3, 2002·Trends in Molecular Medicine·Gregg L Semenza
Jun 5, 2002·Nature Reviews. Cancer·William C Hahn, Robert A Weinberg
Jun 29, 2002·Circulation Research·Ichiro Shiojima, Kenneth Walsh
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Sep 27, 2003·European Journal of Clinical Investigation·G J CaineG Y H Lip
Jan 27, 2004·The American Journal of Pathology·Gelareh ZadehAbhijit Guha
Apr 20, 2004·Cancer Cell·Darren M Brown, Erkki Ruoslahti
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Sep 24, 2004·Experimental Cell Research·Deborah E BrittDouglas C Hixson
Sep 30, 2004·Journal of Neuropathology and Experimental Neurology·Gelareh ZadehAbhijit Guha
Oct 29, 2004·The American Journal of Pathology·Marcia Regina MacheinKarl H Plate
Sep 28, 2005·Biochemical and Biophysical Research Communications·Jun WangDaiming Fan
Jun 16, 2006·The Journal of Biological Chemistry·Edward F RocnikCyrus Vaziri
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Seok-Geun LeePaul B Fisher
Mar 5, 2008·Cancer Research·Devanand SarkarPaul B Fisher
Feb 18, 2009·The Journal of Clinical Investigation·Byoung Kwon YooDevanand Sarkar
Nov 12, 2009·Cancer Research·Devanand SarkarPaul B Fisher

❮ Previous
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Citations

Mar 15, 2011·Cancer Immunology, Immunotherapy : CII·Ben-Jiang QianHui-Zhang Li
Jun 12, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhenzhen ZhouDe'an Tian
Aug 31, 2010·Nature Genetics·Verneri AnttilaUNKNOWN International Headache Genetics Consortium
Dec 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sujit K BhutiaPaul B Fisher
Dec 7, 2013·Neuro-oncology·Timothy P KegelmanPaul B Fisher
May 6, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Cong LiJingshu Geng
Oct 1, 2011·Journal of Virology·Christine E EngelandHans-Georg Kräusslich
Nov 12, 2009·Cancer Research·Devanand SarkarPaul B Fisher
Sep 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dong ChenDevanand Sarkar
Jan 8, 2010·Molecular Cancer Therapeutics·Luni EmdadPaul B Fisher
Dec 3, 2011·Journal of Translational Medicine·Wen-Ting LiaoLi-Bing Song
Apr 5, 2011·Breast Cancer Research : BCR·Mario Andres Blanco, Yibin Kang
Oct 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiasheng ZhengCaixia Hu
Nov 16, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Cong LiJing-Shu Geng
Jun 21, 2014·Clinical & Experimental Metastasis·Sandra CasimiroLuis Costa
Feb 18, 2016·Digestive Diseases and Sciences·Lei ChenHui-Qing Jiang
Jan 23, 2016·Hepatic Oncology·Chadia L RobertsonDevanand Sarkar
Dec 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Hyo-Jeong LeeSung-Hoon Kim
Aug 26, 2010·Gene Expression Patterns : GEP·Hyun Yong JeonPaul B Fisher
Feb 1, 2013·International Journal of Cancer. Journal International Du Cancer·Yong LiuYuanzheng Qiu
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Byoung Kwon YooDevanand Sarkar
Jun 13, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jyoti SrivastavaDevanand Sarkar

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