Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants

Pediatric Research
Nadine El-KhouryPraveen Ballabh

Abstract

Astrocyte end-feet ensheathe blood vessels in the brain and are believed to provide structural integrity to the cerebral vasculature. We sought to determine in developing infants whether the coverage of blood vessels by astrocyte end-feet is decreased in germinal matrix (GM) compared with cerebral cortex and white matter (WM), which may cause fragility of the GM vasculature. Therefore, we evaluated the perivascular coverage by astrocyte end-feet in these areas. We double-labeled the brain sections with astroglial markers [glial fibrillary acidic protein (GFAP), aquaporin-4 (AQP4), and S-100beta] and a vascular marker, laminin. Perivascular coverage by GFAP+ astrocyte end-feet increased consistently as a function of gestational age (GA) in cortex and WM from 19 to 40 wk. Compared with GFAP, AQP4+ astrocyte end-feet developed at an earlier GA, ensheathing about 63% of blood vessels for 23-40 wk in cortex, WM, and GM. Coverage by GFAP+ perivascular end-feet was decreased in GM compared with cortex and WM from 23 to 34 wk. There was no difference in the coverage by AQP4+ end-feet among the three areas in these infants. The expression of AQP4, a water channel molecule, in the astrocyte end-feet was not significantly different betwee...Continue Reading

References

Jan 1, 1992·Journal of Neuropathology and Experimental Neurology·H B Sarnat
Jun 1, 1990·Neuropathology and Applied Neurobiology·M WilkinsonJ E Bell
Jan 1, 1988·Acta Neuropathologica·A SasakiY Ishida
Nov 1, 1987·Neuropathology and Applied Neurobiology·S J Gould, S Howard
Apr 2, 1999·The European Journal of Neuroscience·H WenS Nielsen
Nov 4, 2000·Neurochemical Research·L F EngY L Lee
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jérôme BadautLuca Regli
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mahmood Amiry-MoghaddamOle P Ottersen
Jun 23, 2004·Neurobiology of Disease·Praveen BallabhMaiken Nedergaard
Sep 1, 2004·Acta Neurochirurgica. Supplement·M G RibottaA Privat

❮ Previous
Next ❯

Citations

May 21, 2011·Brain : a Journal of Neurology·Rebecca D Folkerth
Jul 10, 2010·Stroke; a Journal of Cerebral Circulation·Govindaiah VinukondaPraveen Ballabh
Oct 10, 2009·Pediatric Research·Praveen Ballabh
Mar 31, 2010·Pediatric Research·Siri H OpdalTorleiv O Rognum
Aug 19, 2014·Seminars in Ultrasound, CT, and MR·Joel FritzStephen C O'Connor
Aug 24, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·M M A RaetsP Govaert
Oct 11, 2015·Biochimica Et Biophysica Acta·Marc-André LécuyerAlexandre Prat
Jan 24, 2016·Journal of Neuropathology and Experimental Neurology·Vijayaraghava T S RaoJack P Antel
Feb 15, 2014·Clinics in Perinatology·Praveen Ballabh
Apr 9, 2014·Journal of Neuropathology and Experimental Neurology·Philippe LerouxStéphane Marret
Oct 15, 2013·Glia·Jorge Ivan AlvarezAlexandre Prat
May 10, 2008·The American Journal of Pathology·Faisal AdhamiChia-Yi Kuan
Apr 30, 2014·Brain Structure & Function·Lisa K LundeMahmood Amiry-Moghaddam
Jul 23, 2013·Current Opinion in Neurobiology·Julie A SiegenthalerRichard Daneman
Nov 27, 2014·Frontiers in Neuroscience·Ingrid KratzerZinaida S Vexler
Dec 19, 2017·Birth Defects Research·Katerine S SailiThomas B Knudsen
Mar 22, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nadine BrewFlora Y Wong
Aug 14, 2020·Cells·Daan R M G OpheldersTim G A M Wolfs
Sep 24, 2020·Scientific Reports·Manuel RevueltaRaquel Gutiérrez-González
Apr 25, 2018·Fluids and Barriers of the CNS·Midrelle E NoumbissiMonique F Stins
Apr 15, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Dawid SzpechtAgnieszka Seremak-Mrozikiewicz
Feb 11, 2020·Frontiers in Neuroscience·Alexander H BellAtul Malhotra
Aug 6, 2020·Journal of Clinical Medicine·Vianney GilardStéphane Marret
May 24, 2017·Frontiers in Cellular Neuroscience·Lancelot J MillarZoltán Molnár
May 30, 2020·Journal of Neuroinflammation·Clémence DisdierBarbara S Stonestreet
Sep 30, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Zachary A VesoulisAmit M Mathur
Apr 7, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Paola Valdez SandovalVictor García Navarro
Jan 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rukhmani NarayanamurthyLarry D Unsworth
Feb 2, 2021·Frontiers in Cellular Neuroscience·Micaël CarrierMichèle Desjardins
May 5, 2021·Journal of Chemical Neuroanatomy·Johanna Marie Lundesgaard EidahlSiri Hauge Opdal
May 18, 2021·Frontiers in Neurology·Mariya MalovaLuca Antonio Ramenghi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.