Astrocyte-neuronal interactions in epileptogenesis

Journal of Neuroscience Research
Mussie G HaderaUrsula Sonnewald

Abstract

Pentylenetetrazol, kainic acid, or pilocarpine can be used to induce seizures in animal models of epilepsy. The present Review describes disturbances in astrocyte-neuron interactions in the acute, latent, and chronic phases analyzed by magnetic resonance spectroscopy of brain tissue extracts from rats injected with [1-(13)C]glucose and [1,2-(13)C]acetate. The most consistent change after onset of seizures was the decrease in (13)C labeling of glutamate (GLU) from [1-(13) C]glucose regardless of brain area, severity, or duration of the period with seizures and toxin used. In most cases this decrease was accompanied by a reduction in glutamine (GLN) labeling from [1-(13)C]glucose, presumably as a direct consequence of the reduction in labeling of GLU and the GLU-GLN cycle. Amounts of GLN were never changed. Reduction in the content of N-acetyl aspartate (NAA) was first detectable some time after status epilepticus but before the occurrence of spontaneous seizures. This decrease can be an indication of neuronal death and/or mitochondrial impairment and might indicate beginning gliosis. It is known that gliosis occurs in the chronic phase of temporal lobe epilepsy in hippocampus, but astrocyte metabolism appears normal in this phas...Continue Reading

References

Mar 25, 1977·Science·A Martinez-HernandezM D Norenberg
Mar 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M D Norenberg
Jul 1, 1990·Journal of Neuroscience Research·A J CastiglioniE Tiffany-Castiglioni
Jan 1, 1989·British Journal of Clinical Pharmacology·B S Meldrum
Jul 1, 1989·Brain Research. Brain Research Reviews·R S Fisher
May 26, 1972·Brain Research·N M Van GelderT Rasmussen
Jan 1, 1994·Progress in Neurobiology·G Sperk
Feb 1, 1995·Italian Journal of Neurological Sciences·E A Cavalheiro
Dec 1, 1995·Progress in Neurobiology·H F Bradford
Dec 1, 1996·Epilepsy Research·M Khurgel, G O Ivy
Oct 9, 1999·Epilepsy Research·B S MeldrumA G Chapman
Dec 11, 1999·Canadian Journal of Physiology and Pharmacology·C A ShawK Curry
Dec 9, 2000·Developmental Neuroscience·H QuU Sonnewald
Aug 8, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·J Engel
Jul 10, 2002·Epilepsia·Ognen A C PetroffDennis D Spencer
Aug 2, 2002·Epilepsy Research·J P LeiteE A Cavalheiro
Nov 21, 2002·Neurochemistry International·Hong QuUrsula Sonnewald
May 20, 2003·Journal of Neurochemistry·Haytham EloqayliUrsula Sonnewald
May 20, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Torun M MeløUrsula Sonnewald
Jun 11, 2005·Epilepsia·Dieter Schmidt, Wolfgang Löscher
Jul 19, 2005·Nature Reviews. Neuroscience·Wolfgang Löscher, Heidrun Potschka
Aug 24, 2005·Nature Medicine·Guo-Feng TianMaiken Nedergaard
Aug 4, 2006·Glia·Devin K Binder, Christian Steinhäuser
Jun 14, 2008·Journal of Neuroscience Methods·Giulia CuriaMassimo Avoli
May 19, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Kathryn A Giblin, Hal Blumenfeld

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Citations

Dec 8, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N V Gulyaeva
Jan 19, 2018·Molecular Neurobiology·Susmita SilShilpa Buch
Feb 25, 2018·Pharmacological Reports : PR·Krzysztof ŁukawskiStanisław J Czuczwar
Feb 27, 2020·Epilepsy Currents·Richard E Rosch, Chris G Dulla
Nov 30, 2018·Molecular Neurobiology·D OurdevSatyabrata Kar
Nov 23, 2016·Neurochemical Research·Jan Albrecht, Magdalena Zielińska

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