Astrocyte sodium signaling and neuro-metabolic coupling in the brain

Neuroscience
Christine R Rose, J-Y Chatton

Abstract

At tripartite synapses, astrocytes undergo calcium signaling in response to release of neurotransmitters and this calcium signaling has been proposed to play a critical role in neuron-glia interaction. Recent work has now firmly established that, in addition, neuronal activity also evokes sodium transients in astrocytes, which can be local or global depending on the number of activated synapses and the duration of activity. Furthermore, astrocyte sodium signals can be transmitted to adjacent cells through gap junctions and following release of gliotransmitters. A main pathway for activity-related sodium influx into astrocytes is via high-affinity sodium-dependent glutamate transporters. Astrocyte sodium signals differ in many respects from the well-described glial calcium signals both in terms of their temporal as well as spatial distribution. There are no known buffering systems for sodium ions, nor is there store-mediated release of sodium. Sodium signals thus seem to represent rather direct and unbiased indicators of the site and strength of neuronal inputs. As such they have an immediate influence on the activity of sodium-dependent transporters which may even reverse in response to sodium signaling, as has been shown for G...Continue Reading

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Citations

Feb 27, 2016·Glia·Christine R Rose, Alexei Verkhratsky
Jun 18, 2016·Frontiers in Physiology·Paula F KinoshitaCristoforo Scavone
Aug 6, 2016·BioMed Research International·Silvia Chifflet, Julio A Hernandez
Aug 2, 2016·Alcoholism, Clinical and Experimental Research·Louise Adermark, M Scott Bowers
Aug 11, 2016·Glia·Christine R Rose, Alexei Verkhratsky
Jul 28, 2016·Glia·Francesca BosciaLucio Annunziato
Aug 23, 2016·Biochemical and Biophysical Research Communications·Alexei VerkhratskyRobert Zorec
Nov 15, 2017·Cerebral Cortex·Niklas J GerkauChristine R Rose
Feb 9, 2019·The Journal of Physiology·Alexei VerkhratskyChristine R Rose
May 28, 2019·Molecular Neurobiology·Julianna KardosLászló Héja
Jan 20, 2018·Physiological Reviews·Alexei Verkhratsky, Maiken Nedergaard
Sep 9, 2015·Frontiers in Cellular Neuroscience·Hannah M JahnFrank Kirchhoff
May 8, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew D Gaudet, Laura K Fonken
Feb 6, 2017·Journal of Neuroscience Research·Niklas J GerkauChristine R Rose
May 5, 2016·Glia·Vladimir ParpuraRobert Fern
Aug 30, 2018·Frontiers in Cellular Neuroscience·Alexey R BrazheDmitry E Postnov
Dec 7, 2018·Journal of Neuroscience Research·Rodrigo LerchundiChristine R Rose
Dec 5, 2019·Neurochemical Research·Susanne KöhlerJohannes Hirrlinger
Dec 14, 2018·Frontiers in Cellular Neuroscience·Simon L WadleJonathan Stephan
May 28, 2019·Frontiers in Cellular Neuroscience·John Joseph WadeLiam McDaid
Dec 14, 2019·Cell Calcium·Alexei Verkhratsky, Christine R Rose
Jun 3, 2021·International Journal of Molecular Sciences·Michel J A M van PuttenChristine R Rose

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