Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations.

PloS One
Ursula S SandauJacob Raber

Abstract

SynCAM1 is an adhesion molecule involved in synaptic differentiation and organization. SynCAM1 is also expressed in astroglial cells where it mediates astrocyte-to astrocyte and glial-neuronal adhesive communication. In astrocytes, SynCAM1 is functionally linked to erbB4 receptors, which are involved in the control of both neuronal/glial development and mature neuronal and glial function. Here we report that mice carrying a dominant-negative form of SynCAM1 specifically targeted to astrocytes (termed GFAP-DNSynCAM1 mice) exhibit disrupted diurnal locomotor activity with enhanced and more frequent episodes of activity than control littermates during the day (when the animals are normally sleeping) accompanied by shorter periods of rest. GFAP-DNSynCAM1 mice also display high levels of basal activity in the dark period (the rodent's awake/active time) that are attenuated by the psychostimulant D,L-amphetamine, and reduced anxiety levels in response to both avoidable and unavoidable provoking stimuli. These results indicate that disruption of SynCAM1-dependent astroglial function results in behavioral abnormalities similar to those described in animals model of attention-deficit hyperactive disorder (ADHD), and suggest a hitherto u...Continue Reading

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Citations

Feb 11, 2014·Neural Plasticity·Yann BernardinelliIrina Nikonenko
Mar 5, 2013·Neuroscience and Biobehavioral Reviews·Peter R KilleenJoseph A Sergeant
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Jan 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Xiao LiuXiaozhong Peng
Jan 27, 2021·The Journal of Comparative Neurology·Karthik RaviArumugam R Jayakumar
Jul 10, 2021·Molecular and Cellular Neurosciences·Kiyohito MizutaniYoshimi Takai

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Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

Statview
Excel
GraphPad Prism
Kinder Scientific
VitalView®

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