Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders

Frontiers in Cellular Neuroscience
Francesco PetrelliPaola Bezzi

Abstract

The cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not fully understood although it has been shown that various genetic and environmental factors contribute to their etiology. As increasing evidence indicates that astrocytes and microglial cells play a major role in synapse maturation and function, and there is evidence of deficits in glial cell functions in ASDs, one current hypothesis is that glial dysfunctions directly contribute to their pathophysiology. The aim of this review is to summarize microglia and astrocyte functions in synapse development and their contributions to ASDs.

References

May 1, 1989·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S SteffenburgM Bohman
Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Sep 1, 1993·The Biochemical Journal·P N MoynaghL A O'Neill
Sep 12, 1997·Science·F W Pfrieger, B A Barres
Jun 17, 1998·Journal of Neuroimmunology·S GuptaT Lee
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·J K HarrisonL Feng
Feb 7, 2001·Science·E M UllianB A Barres
Jun 12, 2001·Current Opinion in Neurobiology·P Bezzi, A Volterra
Jul 31, 2001·Trends in Neurosciences·L R WatkinsS F Maier
Jul 30, 2004·Early Human Development·Olaf Dammann, Alan Leviton
Nov 17, 2004·Annals of Neurology·Diana L VargasCarlos A Pardo
Feb 15, 2005·Cell·Karen S ChristophersonBen A Barres
Apr 15, 2005·American Journal of Human Genetics·Gabrielle BarnbyUNKNOWN International Molecular Genetics Study of Autism Consortium
Dec 22, 2005·Nature Immunology·Charles N Serhan, John Savill
Mar 21, 2006·Nature·David Stellwagen, Robert C Malenka
May 1, 2007·Behavioural Brain Research·Michael C StevensVince D Calhoun
Jun 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael M HalassaPhilip G Haydon
Sep 7, 2007·Annals of the New York Academy of Sciences·Nicholas M PonzioTim Kreider
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen E P SmithPaul H Patterson
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Monica J CarsonIryna M Ethell
Oct 30, 2007·Nature Neuroscience·Uwe-Karsten Hanisch, Helmut Kettenmann
Nov 9, 2007·Neuron·Maria Chahrour, Huda Y Zoghbi
Dec 18, 2007·Cell·Beth StevensBen A Barres
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D CahoyBen A Barres
Apr 17, 2008·Nature Reviews. Genetics·Brett S Abrahams, Daniel H Geschwind
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samantha L Bailey-BucktroutStephen D Miller
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Genevíève GowingJean-Pierre Julien
Nov 6, 2008·Cell·Raymond J Kelleher, Mark F Bear
Jan 23, 2009·Journal of Neuroimmunology·Xiaohong LiMazhar Malik
Feb 7, 2009·Brain & Development·Xue MingSteven Buyske
Feb 24, 2009·Nature Neuroscience·Nurit BallasGail Mandel
Mar 19, 2009·Journal of Autism and Developmental Disorders·Rebecca E RosenbergWalter E Kaufmann
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Izumi MaezawaLee-Way Jin
Jul 8, 2009·Pediatrics·Hjördís O AtladóttirErik T Parner
Jul 28, 2009·Annual Review of Medicine·Daniel H Geschwind
Nov 12, 2009·Journal of Cell Communication and Signaling·Cagla Eroglu

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Citations

Dec 14, 2016·Annual Review of Physiology·Susanne A WolfHelmut Kettenmann
Jul 14, 2016·Brain Pathology·David A MenassaSteven A Chance
Feb 19, 2017·Brain Research Bulletin·Elena DossiNathalie Rouach
Dec 12, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cynthia M SolekEdward S Ruthazer
Aug 10, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Guang Yang, Alex Shcheglovitov
Aug 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Shane WiebeNahum Sonenberg
Aug 4, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Volkan SolmazOytun Erbaş
Aug 23, 2019·Translational Psychiatry·Abdulsamie M PatelCatherine M Verfaillie
May 16, 2017·Molecular Neurobiology·Md Shamim HossainToshihiko Katafuchi
Dec 14, 2017·Pharmaceuticals·Hans O Kalkman, Dominik Feuerbach
May 6, 2019·International Journal of Molecular Sciences·Ann Katrin SauerAndreas M Grabrucker
Jun 29, 2018·Molecular Autism·Matthew BengerNicholas D Mazarakis
Jan 4, 2019·Molecular Autism·Maria Rosanna BronzuoliCaterina Scuderi
Feb 7, 2020·Neurotoxicity Research·Raju PaudelShamsher Singh
Sep 26, 2020·Nucleic Acids Research·Liting SongXing-Ming Zhao
Dec 29, 2020·Neuroscience and Biobehavioral Reviews·Emilia CarboneViviana Trezza
Jan 23, 2021·Nature Reviews. Immunology·Kristine E Zengeler, John R Lukens
Jan 26, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Geir BjørklundSalvatore Chirumbolo
Jan 28, 2021·RNA Biology·Aida Cardona-AlberichChristopher R Sibley
Nov 17, 2020·Frontiers in Physiology·Nina DirkxSarah Weckhuysen
Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Grazia PerroneAntonio Scilimati
May 2, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Wadzanai ManjeeseThabisile Mpofana
Sep 1, 2020·Brain, Behavior, and Immunity·Luba Sominsky
Jul 2, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Iohanna DeckmannCarmem Gottfried
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Yuhei NishimuraHiroaki Aoyama
Dec 6, 2018·Neuroimmunomodulation·Ana Clara LibermanClaudio A Serfaty
Dec 14, 2021·Frontiers in Immunology·Katiria Soto-DiazAndrew J Steelman
Jan 5, 2022·Cell Regeneration·Xiaoxiang LuYangfei Xiang

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Methods Mentioned

BETA
RNA-Seq
exome-sequencing

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