Astrocytes and oligodendrocytes express different STOP protein isoforms

Journal of Neuroscience Research
M R GalianoM E Hallak

Abstract

Many cell types contain subpopulations of microtubules that resist depolymerizing conditions, such as exposure to cold or to the drug nocodazole. This stabilization is due mainly to polymer association with STOP proteins. In mouse, neurons express two major variants of these proteins, N-STOP and E-STOP (120 kDa and 79 kDa, respectively), whereas fibroblasts express F-STOP (42 kDa) and two minor variants of 48 and 89 kDa. N- and E-STOP induce microtubule resistance to both cold and nocodazole exposure, whereas F-STOP confers microtubule stability only to the cold. Here, we investigated the expression of STOP proteins in oligodendrocytes and astrocytes in culture. We found that STOP proteins were expressed in precursor cells, in immature and mature oligodendrocytes, and in astrocytes. We found that oligodendrocytes express a major STOP variant of 89 kDa, which we called O-STOP, and two minor variants of 42 and 48 kDa. The STOP variants expressed by oligodendrocytes induce microtubule resistance to the cold and to nocodazole. For astrocytes, we found the expression of two STOP variants of 42 and 48 kDa and a new STOP isoform of 60 kDa, which we called A-STOP. The STOP variants expressed by astrocytes induce microtubule resistance ...Continue Reading

References

Jan 1, 1979·Cell Biology International Reports·A D BershadskyI S Tint
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Nov 10, 1992·Biochimica Et Biophysica Acta·F PirolletD Job
Sep 1, 1986·The Journal of Cell Biology·P W Baas, S R Heidemann
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D JobR L Margolis
Apr 29, 1980·Biochemistry·B C Webb, L Wilson
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·C BoscR L Margolis
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·E DenarierD Job
Jun 5, 2003·Genomics·Mustapha AguezzoulEric Denarier

❮ Previous
Next ❯

Citations

Mar 26, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kosuke KajitaniGeorge S Robertson
Aug 21, 2012·The Journal of Biological Chemistry·Christian DelphinAnnie Andrieux
Sep 25, 2012·Schizophrenia Bulletin·Julien VolleMarie-Françoise Suaud-Chagny
Oct 26, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Cristhiaan D OchoaRon Balczon
Feb 25, 2009·Molecular and Cellular Neurosciences·Marion RichardVéronique Pellier-Monnin
May 27, 2008·Journal of Neuroscience Research·David GordonRoss Smith
Oct 26, 2010·Journal of Neurochemistry·Vincent FournetMarie-Pascale Martres
Dec 20, 2014·PloS One·Sylvie Gory-FauréAnnie Andrieux
Oct 20, 2006·Journal of Psychopharmacology·Sharon L EastwoodPaul J Harrison
Jun 15, 2006·Journal of Neuroscience Research·M R GalianoM E Hallak
Nov 23, 2005·Journal of Neuroscience Research·Esteban H OrtizJuana M Pasquini
Jul 14, 2006·The Journal of Biological Chemistry·Sylvie Gory-FauréAnnie Andrieux
Jul 9, 2013·The Journal of Biological Chemistry·Julien LefèvrePatrick A Curmi
Jun 25, 2018·Neuroscience Bulletin·Qiaoqiao ChangFengyun Hu
Feb 17, 2007·Journal of Neuroscience Research·Eiliv BrennerAstrid Nehlig
Feb 13, 2015·Journal of Cell Science·Denis DacheuxMélanie Bonhivers
May 25, 2021·Frontiers in Molecular Neuroscience·Camille CuveillierAnnie Andrieux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.