Astrocytes in Neuropathologies Affecting the Frontal Cortex

Frontiers in Cellular Neuroscience
Ulla-Kaisa PeteriMaija L Castrén

Abstract

To an increasing extent, astrocytes are connected with various neuropathologies. Astrocytes comprise of a heterogeneous population of cells with region- and species-specific properties. The frontal cortex exhibits high levels of plasticity that is required for high cognitive functions and memory making this region especially susceptible to damage. Aberrations in the frontal cortex are involved with several cognitive disorders, including Alzheimer's disease, Huntington's disease and frontotemporal dementia. Human induced pluripotent stem cells (iPSCs) provide an alternative for disease modeling and offer possibilities for studies to investigate pathological mechanisms in a cell type-specific manner. Patient-specific iPSC-derived astrocytes have been shown to recapitulate several disease phenotypes. Addressing astrocyte heterogeneity may provide an improved understanding of the mechanisms underlying neurodegenerative diseases.

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Citations

Jun 4, 2020·Molecular Neurodegeneration·Rajka Maria LiscicEmanuele Buratti
Dec 22, 2019·Stem Cell Reviews and Reports·Raffaella Adami, Daniele Bottai
Oct 16, 2019·Frontiers in Pharmacology·Rosalba SiracusaSalvatore Cuzzocrea
Feb 13, 2021·Brain Sciences·Ulla-Kaisa PeteriMaija L Castrén
Mar 11, 2021·Toxicon : Official Journal of the International Society on Toxinology·Flavia Tasmin Techera AntunesAlessandra Hubner de Souza
Jul 1, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Kasper KatiskoAnnakaisa Haapasalo
Aug 5, 2021·The International Journal of Neuropsychopharmacology·Sierra A CodeluppiMounira Banasr

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Methods Mentioned

BETA
transgenic

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