[Astrocytes in the pathogenesis of multiple sclerosis].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Mika Takarada-Iemata, Osamu Hori


Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), and is designated as an intractable disease in Japan. It is characterized by dissemination of plaque-like sclerosis in space and time, accompanied with various symptoms corresponding to the CNS lesion site. Typically, neurological symptoms chronically progress accompanied with relapses and remissions, and there is still no curative therapy. A number of studies using MS specimen and the animal MS model experimental autoimmune encephalomyelitis (EAE) have shown that MS is an autoimmune disease that targets myelin sheath in the CNS. Autoreactive T cells and B cells play a central role in pathogenesis of MS. MS comprise relapsing-remitting MS and progressive MS, the latter accumulates clinical disability without relapse. Based on the importance of adaptive immunity, various disease-modifying drugs have been developed to treat relapsing-remitting MS. On the other hand, an effective treatment for progressive MS has not yet been established. Increasing evidence have been recognized glial cells as key components of MS immunopathology, in addition to innate immunity and adaptive immunity. However, molecular mechanisms of crosstalk betwe...Continue Reading


Apr 28, 2005·Expert Review of Neurotherapeutics·Richard A Rudick, Alfred Sandrock
Nov 30, 2007·British Journal of Haematology·Wim K BleekerPaul W H I Parren
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roberta BrambillaJohn R Bethea
Apr 20, 2010·Lancet Neurology·Nils Koch-Henriksen, Per Soelberg Sørensen
Aug 6, 2010·Annals of Neurology·Géraldine AndrodiasSerge Nataf
Oct 27, 2010·Annals of Neurology·Roberta MagliozziRichard Reynolds
Jun 1, 2011·Acta Neuropathologica·Richard ReynoldsOwain Howell
Oct 1, 2013·Nature Genetics·UNKNOWN International Multiple Sclerosis Genetics Consortium (IMSGC)Jacob L McCauley
Jun 13, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Monica MorenoDavid Pleasure
Sep 14, 2014·Nature Medicine·Lior MayoFrancisco J Quintana
Dec 3, 2016·Nature Reviews. Neuroscience·Lucile Ben Haim, David H Rowitch
Jan 19, 2017·Nature·Shane A LiddelowBen A Barres
Oct 11, 2017·Trends in Genetics : TIG·Sergio E Baranzini, Jorge R Oksenberg
Jan 10, 2018·Journal of Neurochemistry·Thuong Manh LeOsamu Hori
Jan 11, 2018·The New England Journal of Medicine·Daniel S ReichPeter A Calabresi
Feb 23, 2018·Neuron·Clare Baecher-AllanHoward L Weiner
Jun 22, 2018·Nature Immunology·Rui LiAmit Bar-Or
Jul 19, 2019·Nature·Lucas SchirmerDavid H Rowitch
Aug 11, 2019·Nature Reviews. Drug Discovery·Simon FaissnerV Wee Yong
Jul 21, 2020·Brain, Behavior, and Immunity·Hao ChengJun Tang

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Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

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