Astrocytes in the rat medial amygdala are responsive to adult androgens.

The Journal of Comparative Neurology
Ryan T JohnsonCynthia L Jordan

Abstract

The posterodorsal medial amygdala (MePD) exhibits numerous sex differences including differences in volume and in the number and morphology of neurons and astroctyes. In adulthood, gonadal hormones, including both androgens and estrogens, have been shown to play a role in maintaining the masculine character of many of these sex differences, but whether adult gonadal hormones maintain the increased number and complexity of astrocytes in the male MePD was unknown. To answer this question we examined astrocytes in the MePD of male and female Long Evans rats that were gonadectomized as adults and treated for 30 days with either testosterone or a control treatment. At the end of treatment brains were collected and immunostained for glial fibrillary acidic protein. Stereological analysis revealed that adult androgen levels influenced the number and complexity of astrocytes in the MePD of both sexes, but the specific effects of androgens were different in males and females. However, sex differences in the number and complexity of adult astrocytes persisted even in the absence of gonadal hormones in adulthood, suggesting that androgens also act earlier in life to determine these adult sex differences. Using immunofluorescence and confo...Continue Reading

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Citations

Sep 4, 2013·Hormones and Behavior·Janice M JuraskaLydia L DonCarlos
Jul 16, 2013·The Journal of Pain : Official Journal of the American Pain Society·Nikita N BurkeMichelle Roche
May 20, 2015·Drug and Alcohol Dependence·Marc J KaufmanHarrison G Pope
Dec 15, 2012·The Journal of Comparative Neurology·Ryan T JohnsonCynthia L Jordan
Sep 25, 2012·Psychoneuroendocrinology·Peter A BosErno J Hermans
Nov 26, 2013·Brain Research·Robin M Forbes-LormanAnthony P Auger
Jun 11, 2016·Progress in Neurobiology·Estefanía Acaz-FonsecaGeorge E Barreto
Jan 19, 2016·The Journal of Comparative Neurology·Daniel R PfauCynthia L Jordan
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Kalynn M Schulz, Cheryl L Sisk
Oct 11, 2016·Behavioral and Brain Functions : BBF·Daniel Guerreiro DinizCristovam Wanderley Picanço Diniz
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Jan 24, 2021·Developmental Biology·Kristen L MeehTroy R Shirangi
Mar 27, 2021·Mechanisms of Ageing and Development·Julie A Chowen, Luis M Garcia-Segura

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