Astrocytes promote neurogenesis from oligodendrocyte precursor cells

The European Journal of Neuroscience
P M GaughwinSiddharthan Chandran

Abstract

The oligodendrocyte precursor cell (OPC) has until recently been regarded as a lineage-restricted precursor cell. Considerable interest has been generated by reports suggesting that OPCs may possess a wider differentiation potential than previously assumed and thus be considered a multipotential stem cell. This study examined the neuronal differentiation potential of rat, postnatal cortical OPCs in response to extracellular cues in vitro and in vivo. OPCs did not exhibit intrinsic neuronal potential and were restricted to oligodendrocyte lineage potential following treatment with the neural precursor mitogen fibroblast growth factor 2. In contrast, a postnatal hippocampal astrocyte-derived signal(s) is sufficient to induce functional neuronal differentiation of cortical OPCs in vitro in population and single cell studies. Co-treatment with Noggin, a bone morphogenetic protein antagonist, did not attenuate neuronal differentiation. Following transplantation to the adult rat hippocampus, cortical OPCs expressed doublecortin, a neuroblast-associated marker. The present findings show that hippocampal, astrocyte-derived signals can induce the neuronal differentiation of OPCs through a Noggin-independent mechanism.

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G S EisenbarthM Nirenberg
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L J RichardsP F Bartlett
Apr 1, 1991·Journal of Neuroscience Research·S F Hunter, J E Bottenstein
Jul 1, 1990·Brain Research. Developmental Brain Research·S F Hunter, J E Bottenstein
Jan 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M H WernerL E King
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B RanschtW Seifert
Jan 1, 1995·Annual Review of Neuroscience·F H GageL J Fisher
Sep 1, 1996·Journal of Neuroscience Research·V Avellana-AdalidA Baron-Van Evercooren
Jun 6, 1997·Journal of Neuroscience Methods·A P WrightR J Colello
Dec 3, 1999·Journal of Neuroscience Research·S VitryA Baron-Van Evercooren
Dec 10, 1999·Experimental Cell Research·F Guillemot
Feb 5, 2000·Developmental Neuroscience·W Li, J J LoTurco
Feb 13, 2001·Seminars in Cell & Developmental Biology·M D BootmanP Lipp
Mar 15, 2001·Journal of Neurocytology·S C ZhangI D Duncan
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Jul 5, 2001·Journal of Neurobiology·J M Gensert, J E Goldman
Sep 15, 2001·The European Journal of Neuroscience·J NacherB S McEwen
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I L WeissmanF Gage
Dec 4, 2001·The Journal of Physiology·D ThomasM P Mahaut-Smith
May 3, 2002·Nature·Hongjun SongFred H Gage
Jun 7, 2002·Nature·Kresimir LetinicPasko Rakic
Jul 20, 2002·Trends in Neurosciences·David H RowitchWilliam D Richardson
Apr 18, 2003·Endocrine Reviews·Ernesto CanalisElisabetta Gazzerro
Jul 18, 2003·Journal of Neuroscience Research·Anja Weyer, Karl Schilling
Aug 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yuehua JiangCatherine M Verfaillie
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Martin Raff
Dec 31, 2003·Experimental Neurology·Lowell T McPhailWolfram Tetzlaff

❮ Previous
Next ❯

Citations

Nov 14, 2008·Journal of Biosciences·Pankaj Seth, Nitin Koul
Apr 1, 1993·Journal of Neuroscience Methods·J B SassB H Juurlink
Feb 19, 1993·Brain Research. Developmental Brain Research·B H Juurlink, L Hertz
Jul 28, 2012·Nature Neuroscience·Zaal KokaiaOlle Lindvall
Aug 16, 2011·Stem Cells and Development·Takayuki NakagomiTomohiro Matsuyama
Feb 7, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Siddharthan ChandranRobin J M Franklin
Aug 21, 2007·Journal of Biomaterials Science. Polymer Edition·Erin N Boote Jones, Surya K Mallapragada
Feb 26, 2011·Fluids and Barriers of the CNS·Drew BonkowskiPaula Dore-Duffy
May 4, 2011·Stem Cell Reviews and Reports·Kristien ReekmansPeter Ponsaerts
Jan 16, 2008·Journal of Neurochemistry·Mohammad Raffaqat AnwarMorten Meyer
Aug 28, 2010·Stem Cells·Vidya GopalakrishnanSadhan Majumder
Oct 13, 2006·Progress in Neurobiology·Luca Bonfanti
Nov 15, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Iris KulbatskiCharles H Tator
Oct 27, 2007·Journal of Neuroscience Research·Rui HuaWolfgang Walz
Oct 22, 2008·Nature Reviews. Neuroscience·Robin J M Franklin, Charles Ffrench-Constant
Dec 12, 2019·Neural Regeneration Research·Brian B GriffithsCreed M Stary
Apr 30, 2019·Frontiers in Molecular Neuroscience·Andromachi KarakatsaniCarmen Ruiz de Almodovar
Jun 3, 2021·International Journal of Molecular Sciences·Rina AharoniRuth Arnon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.